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Trial of Vinflunine Versus Alkylating Agent in Metastatic Breast Cancer

2014-08-27 03:15:04 | BioPortfolio

Summary

In metastatic breast cancer (MBC) patients who have already received anthracyclines, taxanes, antimetabolites and vinca-alkaloids and have developed drug resistance to these drugs, therapeutic options are very limited. Alkylating agents showed a modest activity in pretreated metastatic breast cancer. This phase III trial will compare the effectiveness and the safety profile of vinflunine to an alkylating agent of physician choice in MBC patients who have exhausted anthracyclines, taxanes, antimetabolites and vinca-alkaloids.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Breast Cancer

Intervention

vinflunine, alkylating agent of physician choice registered in cancer

Location

Buenos aires
Argentina

Status

Recruiting

Source

Pierre Fabre Medicament

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:04-0400

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Medical and Biotech [MESH] Definitions

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical or radiation breast cancer treatments (e.g., MASTECTOMY).

Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs.

Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.

A synthetic retinoid that is used orally as a chemopreventive against prostate cancer and in women at risk of developing contralateral breast cancer. It is also effective as an antineoplastic agent.

An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA.

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