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A Locally Injected Bradykinin Antagonist for TReatment of OSteoarthritiS

2014-07-23 21:09:46 | BioPortfolio

Summary

The purpose of this study is to determine whether intra-articular (knee joint) administration of MEN16132 is effective reducing the pain from knee osteoarthritis.

Description

MEN16132 is a non-peptide bradykinin B2-receptor antagonist showing analgesic and anti-inflammatory activity in nonclinical osteoarthritis models. This study is being conducted as a dose finding study to determine the safety and efficacy of MEN16132, given as three doses/four treatment regimens in comparison to placebo, as well the time to onset and duration of effect.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Osteoarthritis, Knee

Intervention

MEN16132, MEN16132, MEN16132, MEN16132, placebo control

Location

Hôpital Roger Salengro
Lille
France
59000

Status

Recruiting

Source

Menarini Group

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:46-0400

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