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Clinical Intervention Study in the Primary Care Setting of Patients With High Plasma Fibrinogen (EFAP)

2014-08-27 03:15:06 | BioPortfolio

Summary

Objectives:

- To study the possible effects of an intensive lifestyle change program on, the plasma fibrinogen levels in patients with no cardiovascular disease, with a high fibrinogen and normal cholesterol levels, and moderate Cardiovascular Risk (CVR).

- To analyse whether or not the effect on fibrinogen is independent of the effect on lipids.

Methods: Controlled, randomised clinical trial in 13 Basic Health Areas (BHA) in L'Hospitalet de Llobregat (Barcelona) and Barcelona city. Of the 436 patients between 35 and 75 years with no cardiovascular disease, with a high plasma fibrinogen (> 300 mg/dl) and a plasma cholesterol < 250 mg/dl, 218 received a more frequent and intensive intervention, consisting of advice on lifestyle changes and treatment. The follow up frequency of the intervention group was every two months. The other 218 patients continued with their usual care in the BHAs. Fibrinogen, plasma cholesterol and other clinical biochemistry parameters were assessed.

Study Design

Allocation: Randomized, Control: Historical Control, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Conditions

Cardiovascular Risk Factors

Intervention

Lifestyle intensive group

Location

ABS Florida Sud
L'Hospitalet del Llobregat
Barcelona
Spain
08905

Status

Completed

Source

Jordi Gol i Gurina Foundation

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:06-0400

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