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- To study the possible effects of an intensive lifestyle change program on, the plasma fibrinogen levels in patients with no cardiovascular disease, with a high fibrinogen and normal cholesterol levels, and moderate Cardiovascular Risk (CVR).
- To analyse whether or not the effect on fibrinogen is independent of the effect on lipids.
Methods: Controlled, randomised clinical trial in 13 Basic Health Areas (BHA) in L'Hospitalet de Llobregat (Barcelona) and Barcelona city. Of the 436 patients between 35 and 75 years with no cardiovascular disease, with a high plasma fibrinogen (> 300 mg/dl) and a plasma cholesterol < 250 mg/dl, 218 received a more frequent and intensive intervention, consisting of advice on lifestyle changes and treatment. The follow up frequency of the intervention group was every two months. The other 218 patients continued with their usual care in the BHAs. Fibrinogen, plasma cholesterol and other clinical biochemistry parameters were assessed.
Allocation: Randomized, Control: Historical Control, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research
Cardiovascular Risk Factors
Lifestyle intensive group
ABS Florida Sud
L'Hospitalet del Llobregat
Jordi Gol i Gurina Foundation
Published on BioPortfolio: 2014-08-27T03:15:06-0400
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