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Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology

2014-08-27 03:15:09 | BioPortfolio

Summary

Background:

- Antiretroviral therapy has increased the lifespan of people with human immunodeficiency virus (HIV), but recent research suggests that people with HIV also have an increased risk of developing cardiovascular disease. To better understand the prevalence and effects of heart disease in people with HIV, researchers are interested in comparing heart imaging and metabolism studies to see if there are differences between HIV-positive and HIV-negative people.

Objectives:

- To study metabolism and heart function in people with HIV compared with healthy HIV-negative volunteers.

Eligibility:

- Individuals at least 18 years of age who either have been diagnosed with HIV or are healthy HIV-negative volunteers.

Design:

- Participants will be evaluated with a physical exam, detailed medical history, and routine blood and urine tests including HIV testing.

- Participants will have the following imaging scans:

- Cardiac magnetic resonance imaging (MRI) to study the health of the heart and blood vessels

- Magnetic resonance spectroscopy (MRS) of the heart, liver, and skeletal muscle

- Cardiac computerized tomography (CT) scan to measure calcium levels in the heart and nearby arteries

- Dual-energy x-ray absorptiometry (DEXA) scan to measure body fat and muscle mass.

- Stable isotope infusion to evaluate how the body processes fat (which will require an overnight stay before the test)

- Participants will also have blood tests, an echocardiogram, and an electrocardiogram to evaluate heart function....

Description

HIV is now a chronic infection as patients with access to antiretroviral therapy have significantly improved life expectancies. Patients with HIV also have an increased risk of cardiovascular disease. Thus, cardiovascular disease is an important potential co-morbidity for patients living with HIV. The current proposal will perform a detailed cardiovascular assessment using state-of-the-art imaging techniques to evaluate intramyocardial lipid as well as coronary artery disease and myocardial function in a cohort of 100 HIV infected patients and 30 healthy volunteers as controls. This is an early exploratory cross-sectional study designed to both assess the burden of disease and apply novel techniques in this unique population.

Study Design

N/A

Conditions

HIV

Location

National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda
Maryland
United States
20892

Status

Recruiting

Source

National Institutes of Health Clinical Center (CC)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:09-0400

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