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- Compare the acute effects and tolerability of Dihydroergotamine Mesylate (DHE) delivered by Oral Inhalation (MAP0004) versus by intravenous infusion on Pulmonary Arterial Pressure as determined by echocardiography.
- Assess the Pharmacokinetics of DHE and its metabolites in relation to the parent component.
- Compare the acute effects and tolerability of DHE delivered by Oral Inhalation (MAP0004) versus by intravenous infusion on cardiac function other than pulmonary arterial pressure as determined by echocardiography.
- Compare the pharmacodynamics and pharmacokinetics of DHE delivered by Oral Inhalation (MAP0004) to a single dose of DHE Delivered Intravenously (IV DHE)
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treat
MAP0004, IV Placebo, Placebo Inhaler, DHE 45
Duke Clinical Research Unit
Active, not recruiting
MAP Pharmaceuticals, Inc.
Published on BioPortfolio: 2014-08-27T03:15:09-0400
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