Advertisement

Topics

The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke

2014-08-27 03:15:10 | BioPortfolio

Summary

The purpose of this study is to see whether treating subjects for wrist rehabilitation following stroke with Botox® and robotic therapy is more effective than treatment with robotic therapy alone and no Botox®.

Description

This study will explore new ways to assist with rehabilitation of wrist function after stroke. One of the challenges of wrist recovery is the muscle stiffness or high muscle tone that often makes exercise or therapy difficult. Taking this into account, we propose treating the wrist with a combination of a one-time Botox® injection and a 6-week robotic therapy protocol to maximize recovery. Botox® is a drug that is injected directly into a muscle to temporarily relax the muscle. Botox® is commonly used to decrease muscle tone in tight muscles in the stroke population. Robotic therapy provides highly repetitive movement therapy at the wrist. Subjects will be randomized to two groups. Group A will receive the Botox® injection and group B will receive a placebo saline injection. Both groups will receive the same robotics therapy protocol. Both subjects and investigators will be blinded to group assignment. We would like to know if there are trends between groups in a variety of outcome measures depending on what intervention they received. We predict that the treatment group will have better results than the control group on the Fugl Meyer, our primary outcome measure. We hope the results of this pilot study will guide development of a larger clinical trial.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Stroke

Intervention

Botox®, saline solution

Location

New York Presbyterian Hospital- Weill Cornell campus
New York
New York
United States
10065

Status

Recruiting

Source

New York Presbyterian Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:10-0400

Clinical Trials [2727 Associated Clinical Trials listed on BioPortfolio]

Evaluation of BOTOX® With Rehabilitation Therapy for the Treatment of Wrist and Hand Spasticity in Post-Stroke Patients

The present study is designed to determine the safety and effectiveness of injections of BOTOX® in spastic muscles of the arm and hand compared with injections of saline (which would do n...

Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity

The study seeks to compare the effectiveness of three preparations of BOTOX-A® in treating muscle tightness and spasms in the feet and ankles of people with stroke.

Itch Relieving Effect of Botox: a Study in Healthy Subjects

The purpose of this study is to determine if Botox is effective in the treatment of an experimentally induced itch that mimics chronic itch in healthy volunteers.

Evaluation of Skin Quality Improvement

The purpose of this study is to comprehensively investigate and objectively demonstrate the effectiveness of hyperdiltue Botox® Cosmetic in improving overall skin quality, more specifical...

H-22411: BOTOX® for Peyronie's Disease

Peyronie's disease is a condition in which a plaque, or hard lump, forms on the penis. It causes hardened tissue, pain, and an abnormal bending in the penis. These symptoms are more severe...

PubMed Articles [6140 Associated PubMed Articles listed on BioPortfolio]

Initial Fluid Therapy in Pediatric Diabetic Ketoacidosis: A comparison of Hypertonic Saline Solution and Normal Saline Solution.

The optimal fluid therapy in children with DKA is a matter of debate, especially if we take into account its association with cerebral edema, the most important complication. Hypertonic Saline Solutio...

Chemical denervation using botulinum toxin increases Akt expression and reduces submaximal insulin-stimulated glucose transport in mouse muscle.

Botulinum toxin A (botox) is a toxin used for spasticity treatment and cosmetic purposes. Botox blocks the excitation of skeletal muscle fibers by preventing the release of acetylcholine from motor ne...

Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment.

Periocular povidone-iodine (PI) and polyvinyl alcohol-iodine (PAI) have had a major role in the prevention of endophthalmitis. The purpose of this study was to investigate the corneal epithelial toxic...

Roll off displacement in ex vivo experiments of RF ablation with refrigerated saline solution and refrigerated deionized water.

The recurrence rate in the treatment of liver tumors using radiofrequency ablation (RFA) is often related to incomplete tissue necrosis and consequently the limitation in the ablation volume. This pap...

Evaluation of influence of infusion therapy on the dynamics of acid alkaline balance indices in patients with acute ischemic stroke.

Introduction: The problem of the influence of infusion solutions on the correction of acid alkaline balance disorders in acute ischemic stroke (AIS) remains unclear. The aim: Compare the dynamics of c...

Medical and Biotech [MESH] Definitions

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).

Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration.

Restoration of functions to the maximum degree possible in a person or persons suffering from a stroke.

A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.

A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

More From BioPortfolio on "The Impact of Botox® During Robotic Rehabilitation of the Wrist Following Stroke"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...


Searches Linking to this Trial