Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia

2014-08-27 03:15:11 | BioPortfolio


This is a double blinded, randomised, crossover study with 12 healthy men between 18 and 40 year. The design is based on 6 days:

- day 1: On day time administration of LPS.

- day 2: On night time administration of LPS.

- day 3: On day time administration of LPS + Placebo.

- day 4: On day time administration of LPS + melatonin.

- day 5: On night time administration of LPS + placebo.

- day 6: On night time administration og LPS + melatonin.

Measuring the inflammatoric and oxidative response of LPS and the effect of melatonin compared to placebo on the endotoxaemia.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention


Human Endotoxaemia




Herlev Hospital


Not yet recruiting


Herlev Hospital

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:15:11-0400

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Medical and Biotech [MESH] Definitions

A biogenic amine that is found in animals and plants. In mammals, melatonin is produced by the PINEAL GLAND. Its secretion increases in darkness and decreases during exposure to light. Melatonin is implicated in the regulation of SLEEP, mood, and REPRODUCTION. Melatonin is also an effective antioxidant.

A family of G-protein-coupled receptors that are specific for and mediate the effects of MELATONIN. Activation of melatonin receptors has been associated with decreased intracellular CYCLIC AMP and increased hydrolysis of PHOSPHOINOSITIDES.

A melatonin receptor subtype primarily found expressed in the BRAIN and RETINA.

A melatonin receptor subtype that is primarily found in the HYPOTHALAMUS and in the KIDNEY.

An enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to N-acetylserotonin to form N-acetyl-5-methoxytryptamine (MELATONIN).

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