Biomarkers for Diagnosis of Lung Nodules

2014-08-27 03:15:16 | BioPortfolio


A need exists for non-invasive testing to aid in clinical decision-making for CT scan detected lung nodules of indeterminate etiology. The investigators hypothesize that biomarkers detectable in blood, sputum or urine may be useful for guiding clinical decisions in the setting of CT detected lung nodules to determine which nodules are malignant and which are benign. The investigators also hypothesize that these biomarkers will decrease in concentration to the normal range after successful surgical treatment of malignant lung nodules.


The Biomarkers for Diagnosis of Lung Nodules Study is a prospective study of a cohort of 600 individuals with lung nodules of indeterminate etiology that are identified by CT scans. Either biopsy or repeat CT scans must be clinically indicated to determine the etiology of the nodule. Patients will be asked to allow investigators access to CT scan images and spirometry data, and provide blood, sputum, urine, and exhaled breath samples over the course of the study. Patients will also be asked to allow investigators to access pathology records if a biopsy or surgical excision of the nodule is clinically indicated.

Study Design

Time Perspective: Prospective


Lung Abscess


University of Colorado Anschutz Medical Campus
United States




University of Colorado, Denver

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:15:16-0400

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