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The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery

2014-08-27 03:15:18 | BioPortfolio

Summary

Intravenous Tranexamic acid is used to reduce the hemorrhage during and after cesarean delivery in a double blind randomized placebo controlled trial.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Conditions

Hemorrhage

Intervention

Tranexamic acid, Normal saline

Location

Laleh Eslamian
Tehran
Iran, Islamic Republic of
14114

Status

Recruiting

Source

Tehran University of Medical Sciences

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:18-0400

Clinical Trials [2270 Associated Clinical Trials listed on BioPortfolio]

Tranexamic Acid in Cyanotic Heart Defects

Pediatric patients suffering cyanotic congenital heart disease (CCHD) are prone to excessive surgical bleeding in the early postoperative period and the need for transfusion when exposed t...

Prevention of Postpartum Hemorrhage With TXA

Hemorrhage remains the leading cause of maternal death worldwide. Tranexamic acid has been shown to reduce rates of hemorrhage when given prophylactically prior to cesarean delivery. It ha...

Tranexamic Acid in Preventing Postpartum Hemorrhage in High Risk Pregnancies During Elective Cesarean Section

postpartum hemorrhage (PPT) represents one of the major causes of maternal mortality . Tranexamic acid is used in many studies in management of PPH in combination with ecobolics. this stud...

Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign

The purpose of this study is to determine if computed tomography angiography can predict which individuals with intracerebral hemorrhage will experience significant growth in the size of t...

Effectiveness of Tranexamic Acid When Used as an Adjunct to Misoprostol for the Treatment of Postpartum Hemorrhage

This study is a randomized, double-blind, placebo controlled trial that will enroll 250 women (125 per study arm). The objective of the study is to determine the efficacy and tolerability...

PubMed Articles [12135 Associated PubMed Articles listed on BioPortfolio]

Tranexamic Acid for the Prevention of Blood Loss after Vaginal Delivery.

The use of tranexamic acid reduces mortality due to postpartum hemorrhage. We investigated whether the prophylactic administration of tranexamic acid in addition to prophylactic oxytocin in women with...

The effects of hemorrhage on the pharmacokinetics of tranexamic acid in a swine model.

The early use of tranexamic acid (TXA) is strongly advocated in patients who are likely to require massive transfusion to decrease mortality. This study determines the influence of hemorrhage on the p...

Influence of tranexamic acid on cerebral hemorrhage: A meta-analysis of randomized controlled trials.

Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid...

Nebulized Tranexamic Acid Use for Pediatric Secondary Post-Tonsillectomy Hemorrhage.

Post-tonsillectomy hemorrhage is a frequent occurrence in the emergency department, and management of potentially life-threatening and ongoing bleeding by the emergency physician is challenging. Limit...

Tranexamic acid decreases rodent hemorrhagic shock-induced inflammation with mixed end-organ effects.

Beyond its anti-fibrinolytic mechanism, tranexamic acid has been suggested to have anti-inflammatory properties which may contribute to the survival benefit it provides to trauma patients. The objecti...

Medical and Biotech [MESH] Definitions

Antifibrinolytic hemostatic used in severe hemorrhage.

A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.

A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

Hemorrhage within the orbital cavity, posterior to the eyeball.

A form of compensated hydrocephalus characterized clinically by a slowly progressive gait disorder (see GAIT DISORDERS, NEUROLOGIC), progressive intellectual decline, and URINARY INCONTINENCE. Spinal fluid pressure tends to be in the high normal range. This condition may result from processes which interfere with the absorption of CSF including SUBARACHNOID HEMORRHAGE, chronic MENINGITIS, and other conditions. (From Adams et al., Principles of Neurology, 6th ed, pp631-3)

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