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A Post Marketing Observational Study (PMOS) of the Quality of Life in Adalimumab Treated Psoriasis Patients Failing Other Biological Disease Modifying Anti-rheumatic Drugs (BDMARDs) Over 1 Year

2014-08-27 03:15:18 | BioPortfolio

Summary

The aim of this PMOS is to obtain further data on long-term safety, efficacy and the evaluation of quality of life outcomes of the HUMIRA-Pen in routine clinical use in patients with Moderate to Severe Chronic Plaque Psoriasis after unsustainable clinical response to other biological disease modifying anti-rheumatic drugs (BDMARDs). There are no data so far, showing the effects of switching from other BDMARDs to Humira in patients with Moderate to Severe Chronic Plaque Psoriasis. This study is to evaluate the long-term effectiveness of Humira in patients with moderate to severe chronic plaque psoriasis - by using the PASI - in patients who are pre-treated with efalizumab, infliximab or etanercept and who either never achieved satisfactory response, achieved satisfactory response initially, but lost it over time, discontinued treatment due to intolerance/side effect(s), or other reasons for example after regular stop of etanercept.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Moderate to Severe Plaque Psoriasis

Location

Site Reference ID/Investigator# 27435
Feldkirch
Austria
6807

Status

Active, not recruiting

Source

Abbott

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:18-0400

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PubMed Articles [7201 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A humanized monoclonal antibody that binds to IL-12 and IL-23 and is used as a DERMATOLOGIC AGENT in the treatment of patients with plaque PSORIASIS who have not responded to other therapies.

A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain.

Endovascular procedure in which atheromatous plaque is excised by a cutting or rotating catheter. It differs from balloon and laser angioplasty procedures which enlarge vessels by dilation but frequently do not remove much plaque. If the plaque is removed by surgical excision under general anesthesia rather than by an endovascular procedure through a catheter, it is called ENDARTERECTOMY.

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