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The aim of this PMOS is to obtain further data on long-term safety, efficacy and the evaluation of quality of life outcomes of the HUMIRA-Pen in routine clinical use in patients with Moderate to Severe Chronic Plaque Psoriasis after unsustainable clinical response to other biological disease modifying anti-rheumatic drugs (BDMARDs). There are no data so far, showing the effects of switching from other BDMARDs to Humira in patients with Moderate to Severe Chronic Plaque Psoriasis. This study is to evaluate the long-term effectiveness of Humira in patients with moderate to severe chronic plaque psoriasis - by using the PASI - in patients who are pre-treated with efalizumab, infliximab or etanercept and who either never achieved satisfactory response, achieved satisfactory response initially, but lost it over time, discontinued treatment due to intolerance/side effect(s), or other reasons for example after regular stop of etanercept.
Observational Model: Cohort, Time Perspective: Prospective
Moderate to Severe Plaque Psoriasis
Site Reference ID/Investigator# 27435
Active, not recruiting
Published on BioPortfolio: 2014-08-27T03:15:18-0400
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A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain.
Endovascular procedure in which atheromatous plaque is excised by a cutting or rotating catheter. It differs from balloon and laser angioplasty procedures which enlarge vessels by dilation but frequently do not remove much plaque. If the plaque is removed by surgical excision under general anesthesia rather than by an endovascular procedure through a catheter, it is called ENDARTERECTOMY.
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For-profit enterprise with relatively few to moderate number of employees and low to moderate volume of sales.
Psoriasis is a common skin condition affecting 2-3% of the population of the United Kingdom, where the skins replacement process is sped taking 2-6 days instead of the usual 21 - 28 days for the replacement of skin cells. Patients experience an accumulat...
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...