OTO-104 for Meniere's Disease

2014-07-23 21:09:52 | BioPortfolio


The purpose of this study is to evaluate the safety of OTO-104 in subjects with unilateral Meniere's disease. The effectiveness of OTO-104 to reduce the symptoms of Meniere's disease will also be evaluated.


Meniere's disease is a debilitating disorder of the inner ear which includes symptoms such as vertigo, tinnitus, hearing loss and aural fullness. Meniere's disease may result from an imbalance of fluid in the inner ear. Several studies have shown that corticosteroids may help manage this imbalance yet the effect does not last very long. OTO-104 is a longer lasting corticosteroid which could provide significant benefit to patients with Meniere's disease.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Meniere's Disease


OTO-104 (steroid) 3 mg, Placebo, OTO-104 (steroid) 12 mg


House Ear Institute
Los Angeles
United States




Otonomy, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:09:52-0400

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