Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies
Published on BioPortfolio: 2014-11-05T01:27:39-0500
Clinical Trials
A Study to Evaluate the Safety and Pharmacokinetics of SAR650984 in Patients With Multiple Myeloma
Primary Objective: To evaluate the safety of SAR650984 in patients with relapsed/refractory multiple myeloma (RRMM). Secondary Objective: To determine the pharmacokinetics (...
SAR650984 Combined to CyBorD in Newly Diagnosed Multiple Myeloma (MM) Non Eligible for Transplant
Primary Objective: To determine the maximum tolerated dose (MTD) and recommended dose (RD) of SAR650984 when administered in combination with bortezomib, cyclophosphamide, and dexamethaso...
SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients
Primary Objective: Safety Secondary Objective: Efficacy, Pharmacokinetics (PK)
MS Detection of Somatic Mutations in Hematological Malignancies
Detection of somatic mutations in hematological malignancies is now routinely assessed by NGS sequencing. This powerful approach is nevertheless time consuming and its costs represent limi...
Clinical Implications of Azole-Resistant Aspergillosis in Hematological Malignancy
In order to determine the efficacy of antifungal therapy in patients with documented azole-resistant invasive Aspergillosis (IA), anonymized clinical information of patients with a hematol...
PubMed Articles
Effects of GST variants on the risk odds of hematological malignancy: A meta-analysis.
Whether glutathione S-transferases (GST) polymorphisms influence the risk odds of hematological malignancy remains controversial. Therefore, we performed this meta-analysis to better analyze correlati...
Hematological malignancies presenting as spontaneous tumor lysis syndrome: A case series.
Tumor lysis syndrome is an oncological emergency caused by massive tumor lysis resulting in a constellation of metabolic abnormalities. It is observed most frequently in patients with high-grade hemat...
Mucormycosis is an opportunistic infection occurring in immunocompromised hosts with hematological malignancies. Mortality due to mucormycosis in patients with hematological malignancy is high. Howeve...
Prospective data on fatigue in elderly persons with a hematological malignancy are rare. We aimed to determine the prevalence of fatigue and its association with clinical outcome and geriatric impairm...
Exaggerated insect bite reactions present as exuberant papular and vesiculobullous lesions in patients with hematologic malignant neoplasms. The most commonly reported hematological malignancy with ex...
Medical and Biotech [MESH] Definitions
Hirudin Therapy
Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.
Mianserin
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Mardivirus
A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.
Acute Radiation Syndrome
A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
Exophthalmos
Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.
