Phase 1/2 Dose Escalation and Efficacy Study of Anti-CD38 Monoclonal Antibody in Patients With Selected CD38+ Hematological Malignancies
Published on BioPortfolio: 2014-11-05T01:27:39-0500
Clinical Trials
A Study to Evaluate the Safety and Pharmacokinetics of SAR650984 in Patients With Multiple Myeloma
Primary Objective: To evaluate the safety of SAR650984 in patients with relapsed/refractory multiple myeloma (RRMM). Secondary Objective: To determine the pharmacokinetics (...
SAR650984 Combined to CyBorD in Newly Diagnosed Multiple Myeloma (MM) Non Eligible for Transplant
Primary Objective: To determine the maximum tolerated dose (MTD) and recommended dose (RD) of SAR650984 when administered in combination with bortezomib, cyclophosphamide, and dexamethaso...
SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients
Primary Objective: Safety Secondary Objective: Efficacy, Pharmacokinetics (PK)
Clinical Implications of Azole-Resistant Aspergillosis in Hematological Malignancy
In order to determine the efficacy of antifungal therapy in patients with documented azole-resistant invasive Aspergillosis (IA), anonymized clinical information of patients with a hematol...
The purpose of this study is to determine the safety and anti-tumor effects of an experimental immunotherapy drug, called AlloStim, which is intentionally mis-matched immune cells which ar...
PubMed Articles
Background As relapsed disease is frequently the first target of newly developed therapies, it is vital to address the difficulty in demonstrating the efficacy of new drugs for relapsed malignancy in ...
Teicoplanin is a glycopeptide antibiotic currently used for the treatment of methicillin-resistant Staphylococcus aureus. The need for therapeutic drug monitoring of teicoplanin has been increasingly ...
Fibroadenoma is overwhelmingly the most common pediatric breast lesion. Breast malignancy is quite uncommon in children, most frequently metastatic or hematological malignancy. Core biopsy has largely...
Medical staff often overlook or underestimate the presence or severity of cognitive dysfunction. The purpose of this study was to clarify the frequency, clinical indicators and predictors of cognitive...
Hematological Analysis in Thai Samples With Deletional and Nondeletional HbH Diseases.
To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups.
Medical and Biotech [MESH] Definitions
Hirudin Therapy
Use of HIRUDINS as an anticoagulant in the treatment of cardiological and hematological disorders.
Mianserin
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Mardivirus
A genus in the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, associated with malignancy in birds.
Acute Radiation Syndrome
A condition caused by a brief whole body exposure to more than one sievert dose equivalent of radiation. Acute radiation syndrome is initially characterized by ANOREXIA; NAUSEA; VOMITING; but can progress to hematological, gastrointestinal, neurological, pulmonary, and other major organ dysfunction.
Exophthalmos
Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.
