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Study to Evaluate the Efficacy, Safety and Tolerability of N1539

2014-08-27 03:15:18 | BioPortfolio

Summary

To determine the analgesic efficacy, duration of effect, and safety of single doses of N1539 in subjects undergoing open abdominal hysterectomy

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Hysterectomy

Intervention

N1539, N1539, N1539, N1539, placebo, Morphine, N1539

Location

Tbilisi
Georgia
0186

Status

Recruiting

Source

Elan Drug Delivery Inc

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:18-0400

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PubMed Articles [1197 Associated PubMed Articles listed on BioPortfolio]

Transversus Abdominis Plane Block for Post Hysterectomy Pain: A Systematic Review and Meta-Analysis.

The objective of this study was to address the efficacy of transversus abdominis plane (TAP) blocks in pain management among women who undergo elective hysterectomy for benign pathology in both open a...

Effects of intramuscular morphine in men and women with temporomandibular disorder with myofascial pain.

This placebo-controlled randomized double-blinded clinical study assessed the analgesic efficacy of intramuscular morphine in TMD patients with myofascial pain and sex dependent responses of the morph...

Intrathecal Morphine Following Lumbar Fusion: A Randomized, Placebo-Controlled Trial.

Despite the potential for faster postoperative recovery and the ease of direct intraoperative injection, intrathecal morphine is rarely provided in lumbar spine surgery.

The role of the vasopressin system and dopamine D1 receptors in the effects of social housing condition on morphine reward.

The association with opioid-abusing individuals or even the perception of opioid abuse by peers are risk factors for the initiation and escalation of abuse. Similarly, we demonstrated that morphine-tr...

Hysterectomy status and all-cause mortality in a 21-year Australian population-based cohort study.

Hysterectomy is a common surgical procedure, predominantly performed when women are between 30 and 50 years old. One in three women in Australia has had a hysterectomy by the time they are 60 years ol...

Medical and Biotech [MESH] Definitions

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.

Strong dependence, both physiological and emotional, upon morphine.

Analogs or derivatives of morphine.

Excision of the uterus.

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