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Continuous Control of Tracheal Cuff Pressure and Microaspiration in Critically Ill Patients

2014-08-27 03:15:23 | BioPortfolio

Summary

We hypothesized that continuous control of tracheal cuff pressure would reduce microaspiration of gastric content as determined by pepsin level in tracheal aspirate.

Description

Randomized controlled open label study, performed in a 10-bed ICU. All patients intubated with a PVC-cuffed tracheal tube and receiving enteral nutrition who require at least 48 h of mechanical ventilation are eligible. Patients receive continuous control of cuff pressure using a pneumatic device (intervention group) or manual control using a manometer (control group). Target cuff pressure is 25 cmH2O.

In all patients, pepsin is measured in tracheal aspirate during a 48-h period after inclusion, as proxy for gastric content aspiration. In addition tracheobronchial colonization and ventilator associated pneumonia rates will be compared between the two groups.

Study Design

Allocation: Randomized, Control: Active Control, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Conditions

Critically Ill

Intervention

Continuous control of cuff pressure, Manual control of cuff pressure

Location

ICU, Calmette Hospital, University Hospital of Lille
Lille
Nord
France
59037

Status

Recruiting

Source

University Hospital, Lille

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:23-0400

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