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Antiarrythmic Drugs - Long-term Follow-up in the Modern Era

2014-08-27 03:15:24 | BioPortfolio

Summary

Antiarrhythmic drugs are associated with significant side effect profiles. Amiodarone has primarily class III action and whilst it has unrivalled efficacy in management of certain arrhythmias, it has a formidable side effect profile. Complications of continued therapy include, thyroiditis, hepatitis, cholestasis, increased skin sensitivity and pulmonary fibrosis. Current prescribing guidelines recommend frequent blood tests to monitor kidney, liver and thyroid function, in addition to frequent pulmonary function tests. Sotalol is a betablocker which possesses class III action in high doses and may predispose to QT prolongation Other class I agents such as flecainide and propafenone can be associated with sudden cardiac death in certain populations, and may predispose to other arrhythmias.

This study will examine the incidence of discontinuation of AAD therapy and adverse events.

Study Design

Observational Model: Ecologic or Community, Time Perspective: Retrospective

Conditions

Cardiac Dysrhythmia

Location

Univeristy of Dundee
Dundee
United Kingdom
DD1 9SY

Status

Active, not recruiting

Source

University of Dundee

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:24-0400

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