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Phase I Study To Test The Safety of TVAX Immunotherapy As A Treatment For Recurrent Grade III/IV Gliomas

2014-08-27 03:15:25 | BioPortfolio

Summary

TVAX Immunotherapy is an experimental treatment that takes advantage of the fact that your body can produce immune cells, called 'killer' white blood cells that have the ability to kill large numbers of the cancer cells that are present in your body. TVAX immunotherapy is designed to generate large numbers of those 'killer' white blood cells and to deliver those cells into your body so that they can kill your cancer cells.

Description

The TVAX Immunotherapy involves several steps. First, the patient's cancer will be surgically removed to provide cells for the vaccine. Second, the patient will be vaccinated twice with those cells and GM-CSF. Third, the patient's blood will be filtered for white cells which will then be cultured and stimulated to reach a higher (killer) activity level. Fourth, the activated white blood cells will be infused into the patient's bloodstream so that they will be able to attack the cancer. Fifth, the patient will receive a course of low-dose interleukin-2 (IL-2), which stimulates the activated white blood cells to continue to multiply after they are in the body. Finally, the entire process starting with vaccination and ending with IL-2 injections will be repeated, for a total of two rounds of therapy.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Glioma

Intervention

Cancer vaccine plus immune adjuvant, plus activated white blood cells

Location

Saint Luke's Hospital
Kansas City
Missouri
United States
64111

Status

Recruiting

Source

TVAX Biomedical

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:25-0400

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