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Daptomycin as Antibiotic Prophylaxis of Sternal Wound Infections

2014-07-23 21:09:55 | BioPortfolio

Summary

The purpose of this study is to show that the incidence of sternal wound infections at day 30 after cardiac surgery is 50% lower with the additional use of Daptomycin on top of a standard antibiotic prophylaxis as compared to the standard antibiotic prophylaxis alone.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Wound Infection

Intervention

Daptomycin, Cefuroxime

Location

Hannover Medical School, Department of Cardiothoracic, Transplant and Vascular surgery
Hannover
Germany

Status

Recruiting

Source

Hannover Medical School

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:09:55-0400

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PubMed Articles [7400 Associated PubMed Articles listed on BioPortfolio]

High-dose daptomycin in patients with infective endocarditis or sternal wound infections.

Prevention of deep sternal wound infection in cardiac surgery, review of literature.

Deep sternal wound infection is a dreaded complication of cardiac surgery with considerable consequences in terms of mortality, morbidity and treatment costs. Multiple specific measures in the prevent...

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Medical and Biotech [MESH] Definitions

The application of a vacuum across the surface of a wound through a foam dressing cut to fit the wound. This removes wound exudates, reduces build-up of inflammatory mediators, and increases the flow of nutrients to the wound thus promoting healing.

Infection occurring at the site of a surgical incision.

Intraocular infection caused mainly by pus-producing bacteria and rarely by fungi. The infection may be caused by an injury or surgical wound (exogenous) or by endogenous septic emboli in such diseases as bacterial endocarditis or meningococcemia.

Invasion of the site of trauma by pathogenic microorganisms.

A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

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