Effects on Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients

2014-07-24 14:07:18 | BioPortfolio


COPD patients have a reduced exercise tolerance due to a ventilatory limitation.

Several studies have shown altered skeletal muscle function. The investigator want to study the physiological response to knee-extensor exercise in COPD patients.


Reduced exercise tolerance is one of the hallmarks of COPD and The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contributes to this impairment . Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction

Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation.

We therefore want conduct a study to investigate training effects in patients with moderate to severe COPD with special focus on skeletal muscle.

The COPD patients will therefore perform high intensity aerobic interval knee-extensor exercise training 3 days/week for six weeks . At baseline and followup, muscle oxygen consumption and mitochondrial respiration will be measured.

Study Design

Allocation: Non-Randomized, Control: Active Control, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science




High intensity knee-extensor training


Active, not recruiting


Norwegian University of Science and Technology

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:07:18-0400

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