Study With Two Different Doses of Desmopressin Melt Tablet With Nocturnal Enuresis
Summary
This is multi-center, randomized, placebo-controlled, parallel-group, double-blind, dose-escalating clinical trial designed to assess the efficacy and safety of desmopressin lyophilisate for the treatment of nocturnal enuresis "with decreased nighttime urinary osmolality."
Study Design
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
Conditions
Nocturnal Enuresis
Intervention
Desmopressin, Placebo
Location
Shinko-kakogawa hospital
Kakogawa
Hyogo
Japan
Status
Recruiting
Source
Ferring Pharmaceuticals
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01078753
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-07-23T21:09:57-0400
Clinical Trials
The aim of this study is to investigate the importance of clinical characterization of children with monosymptomatic nocturnal enuresis (MNE) in order to improve treatment efficacy. ...
Patients suffering from nocturnal enuresis (starting from the age of 5 till adulthood) are all treated with the same dose of desmopressin, i.e. 120mcg once daily. In treatment resistant en...
Study on Chinese and Western Medicine in MNE Children
Monosymptomatic nocturnal enuresis (MNE) is a common pediatric developmental disorder. MNE refers to urinary incontinence in the sleep state in children aged >5 years, without other LUT sy...
Monosymptomatic nocturnal enuresis (MEN) is a common problem in children, affecting 7-10% of all 7 year olds. MEN is often leading to psychosocial problems because of its burden and stigma...
Desmopressin as a Therapy for Bedwetting in Children With Sickle Cell Disease
This study assesses if using the medication desmopressin will decrease nightime bedwetting in children with sickle cell disease. Half of the children will receive placebo and half of the c...
PubMed Articles
Constipation in nocturnal enuresis may interfere desmopressin management success.
Previous studies indicated that the prevalence of constipation in enuretic patients is higher than that in the general population. Several studies have revealed that successful treatment of constipati...
To assess the efficacy of desmopressin (D), alarm (A), desmopressin plus alarm (DA), and desmopressin plus anticholinergic agent (DAA) in the management of pediatrics monosymptomatic nocturnal enuresi...
Nocturnal enuresis in children is associated with differences in autonomic control.
To assess the relationship between urine osmolality, cardiovascular parameters, and nocturnal enuresis in a population of children undergoing polysomnographic assessment.
Primary nocturnal enuresis: a novel therapeutic strategy with higher efficacy.
To introduce a new protocol for patients with primary nocturnal enuresis to increase efficacy of treatment and decrease relapse rate.
A comprehensive review of adult enuresis.
Nocturnal enuresis (NE) is a combined symptom of nocturia and urinary incontinence. In this review, we aim to summarize the current literature on NE in terms of its definition, diagnosis, and manageme...
Medical and Biotech [MESH] Definitions
Enuresis
Involuntary discharge of URINE after expected age of completed development of urinary control. This can happen during the daytime (DIURNAL ENURESIS) while one is awake or during sleep (NOCTURNAL ENURESIS). Enuresis can be in children or in adults (as persistent primary enuresis and secondary adult-onset enuresis).
Nocturnal Enuresis
Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.
Myoclonus
Involuntary shock-like contractions, irregular in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles. This condition may be a feature of some CENTRAL NERVOUS SYSTEM DISEASES; (e.g., EPILEPSY, MYOCLONIC). Nocturnal myoclonus is the principal feature of the NOCTURNAL MYOCLONUS SYNDROME. (From Adams et al., Principles of Neurology, 6th ed, pp102-3).
Diurnal Enuresis
Involuntary discharge of URINE during the daytime while one is awake.
Therapeutic Misconception
Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.
