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Bumentanide Protocol

2014-08-27 03:15:31 | BioPortfolio

Summary

The purpose of this study is to determine if a treatment by bumetanide presents an efficiency at the level of the neuronal maturation in the autism

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Autistics Children

Intervention

bumetanide

Status

Active, not recruiting

Source

University Hospital, Brest

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:31-0400

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Pilot Study of Bumetanide for Newborn Seizures

The main goal of the study is to obtain pharmacokinetic and safety data of bumetanide in newborns with refractory seizures. The overall hypothesis is that bumetanide, added to conventional...

Evaluation of the Efficiency of Treatment by BUMETANIDE on Autistic Children With a Known Ethiology

During a previous therapeutic trial, investigators showed that the bumetanide improved significantly autism. This trial showed that a therapeutic response was obtained in 75% of cases. ...

Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects

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Bumetanide in Hypokalaemic Periodic Paralysis

This is a randomised, double-blind, placebo-controlled phase II clinical trial with a cross-over design to investigate the efficacy of bumetanide in patients with hypokalemic periodic para...

EEG Studies of Sensory Processing in Autistic Children

This study uses EEG to study brain waves at rest and in response to specific auditory and visual sensory stimuli in autistic children. We hypothesize that, compared to same age peers, aut...

PubMed Articles [6474 Associated PubMed Articles listed on BioPortfolio]

Application of a Physiologically-Based Pharmacokinetic Model for the Prediction of Bumetanide Plasma and Brain Concentrations in the Neonate.

Bumetanide is a loop diuretic that is proposed to possess a beneficial effect on disorders of the central nervous system, including neonatal seizures. Therefore, prediction of unbound bumetanide conce...

Inhibition of Nkcc1 Promotes Axonal Growth and Motor Recovery in Ischemic Rats.

Bumetanide is a selective inhibitor of the Na(+)-K(+)-Cl(-)-co-transporter 1(NKCC1). We studied whether bumetanide could affect axonal growth and behavioral outcome in stroke rats. Adult male Wistar r...

Neurodevelopment in Young Children Born to HIV-Infected Mothers: A Meta-analysis.

HIV-infected (HIV+) children have worse neurodevelopmental outcomes compared with HIV-uninfected children. However, little is known regarding the differences in neurodevelopment between young HIV+ chi...

NKCC1 Inhibition Attenuates Chronic Cerebral Hypoperfusion-Induced White Matter Lesions by Enhancing Progenitor Cells of Oligodendrocyte Proliferation.

Cerebral white matter is vulnerable to ischemic condition. However, no effective treatment to alleviate or restore the myelin damage caused by chronic cerebral hypoperfusion has been found. Na-K-Clcot...

The association between punishment and cooperation in children with high-functioning autism.

This study examined judgment about punishment and whether punishment promoted cooperation in the prisoner's dilemma game (PDG) in children with high-functioning autism (HFA) and typically developing (...

Medical and Biotech [MESH] Definitions

A sulfamyl diuretic.

Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.

Children who have reached maturity or the legal age of majority.

Children with mental or physical disabilities that interfere with usual activities of daily living and that may require accommodation or intervention.

Financial assistance provided by the government to indigent families with dependent children who meet certain requirements as defined by the Social Security Act, Title IV, in the U.S.

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