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The purpose of the study is to determine the influence of luteinizing hormone releasing hormone (LHRH) analogue - Lucrin Depot 11,25 mg (Lucrin Depot 3,75mg - in Ukraine) administration on intensity of lower urinary tract symptoms (LUTS) in patients with diagnosed locally advanced and/or metastatic prostatic cancer and LUTS.
The remaining targets are:
- to assess the intensity of LUTS in population of polish patients with locally advanced and/or metastatic prostatic cancer, previously untreated with hormonal therapy,
- to assess the prevalence of other symptoms in population of polish patients with locally advanced and/or metastatic prostatic cancer (such as: hematospermia, epigastric pain, urine incontinence, erection disturbances, crotch pain, anal pain or bleeding, lumbar/back pain, bones pain, spinal compression symptoms, peripheral lymph nodes enlargement, lymphatic oedema of lower extremities),
- to assess the influence of LHRH analogue (Lucrin Depot 11,25 mg in Poland, Lucrin Depot 3,75mg in Ukraine) administration on intensity of other symptoms in patients with prostatic cancer,
- to provide data on safety of Lucrin Depot treatment during 15-month therapy course
Observational Model: Case-Only, Time Perspective: Prospective
Advanced Prostate Cancer
Leuprolide acetate Depot Susp. 11,25 mg (Poland), 3,75 mg (Ukraine)
Site Reference ID/Investigator# 31076
Active, not recruiting
Published on BioPortfolio: 2014-08-27T03:15:31-0400
The purpose of this research study is to determine the effects of abiraterone acetate plus leuprolide acetate and prednisone versus leuprolide acetate alone on hormone levels in the blood ...
The purpose of this study is to access the efficacy and safety of two new formulations of leuprolide acetate 45 mg 6-month depot formulations in treating patients with prostate cancer.
This Phase 2a, pharmacokinetic/pharmacodynamic study will determine the safety and provide evaluation of the PK/PD metrics of two different oral doses selected upon the results of the stud...
The purpose of this study is to look at the efficacy and safety of leuprolide acetate in patients with prostate cancer.
RATIONALE: Androgens can cause the growth of prostate cancer cells. Antihormone therapy, such as abiraterone acetate, leuprolide acetate, and goserelin, may lessen the amount of androgens ...
Children with central precocious puberty (CPP) are treated with gonadotropin-releasing hormone agonists (GnRHa) to suppress puberty. Optimizing treatment outcomes continues to be studied. The relation...
To describe women's experiences with subcutaneous depot medroxyprogesterone acetate (DMPA-SC) to inform scale-up of self-administered DMPA-SC.
Introduction: The scale and socio-economic implications of the non-communicable diseases (NCD) epidemic are growing in Ukraine. The aim: To determine the mode of mortality resulted from main non-commu...
The literature lacks data on the use of the gold-standard hyperinsulinemic-euglycemic clamp (HEC) technique for the evaluation of insulin resistance (IR) in depot-medroxyprogesterone acetate (DMPA) us...
To assess the effect of the depot medroxyprogesterone acetate injectable (DMPA) and of the levonorgestrel (LNG)-implant on genital HIV shedding among women receiving antiretroviral therapy (ART).
Country in Europe, bordering the Black Sea, between Poland, Romania, and Moldova in the west and Russia in the east. The capital is Kyiv.
Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.
An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
Endocrine disorders are grouped into two categories: hormone imbalance - when a gland produces too much or too little of an endocrine hormone development of lesions (such as nodules or tumors) in the endocrine system, which may or may not affect...
Diabetes Diabetes Endocrine Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several groups of h...
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...