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The purpose of the study is to determine the influence of luteinizing hormone releasing hormone (LHRH) analogue - Lucrin Depot 11,25 mg (Lucrin Depot 3,75mg - in Ukraine) administration on intensity of lower urinary tract symptoms (LUTS) in patients with diagnosed locally advanced and/or metastatic prostatic cancer and LUTS.
The remaining targets are:
- to assess the intensity of LUTS in population of polish patients with locally advanced and/or metastatic prostatic cancer, previously untreated with hormonal therapy,
- to assess the prevalence of other symptoms in population of polish patients with locally advanced and/or metastatic prostatic cancer (such as: hematospermia, epigastric pain, urine incontinence, erection disturbances, crotch pain, anal pain or bleeding, lumbar/back pain, bones pain, spinal compression symptoms, peripheral lymph nodes enlargement, lymphatic oedema of lower extremities),
- to assess the influence of LHRH analogue (Lucrin Depot 11,25 mg in Poland, Lucrin Depot 3,75mg in Ukraine) administration on intensity of other symptoms in patients with prostatic cancer,
- to provide data on safety of Lucrin Depot treatment during 15-month therapy course
Observational Model: Case-Only, Time Perspective: Prospective
Advanced Prostate Cancer
Leuprolide acetate Depot Susp. 11,25 mg (Poland), 3,75 mg (Ukraine)
Site Reference ID/Investigator# 31076
Active, not recruiting
Published on BioPortfolio: 2014-08-27T03:15:31-0400
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Country in Europe, bordering the Black Sea, between Poland, Romania, and Moldova in the west and Russia in the east. The capital is Kyiv.
Proteins secreted by the prostate gland. The major secretory proteins from the human prostate gland include PROSTATE-SPECIFIC ANTIGEN, prostate-specific acid phosphatase, prostate-specific membrane antigen, and prostate-specific protein-94.
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A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
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