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Alzheimer`s Disease Acitretin Medication

2014-08-27 03:15:34 | BioPortfolio

Summary

The trials investigates the changes of cerebral spinal fluid APPSα levels under oral therapy with acitretin 30mg daily in patients with mild to moderate Alzheimer's disease.The present study aims to demonstrate an enhancement of the α-secretase activity by acitretin as measured by increased CSF APPSα levels in human AD. Second, the safety and tolerability of acitretin in AD patients should be proven.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Alzheimer Disease

Intervention

Acitretin, Placebo

Location

Department of psychiatry and psychotherapy, University medical center of the Johannes Gutenberg-University Mainz
Mainz
Rheinland-Pfalz
Germany
55131

Status

Not yet recruiting

Source

Johannes Gutenberg University Mainz

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:34-0400

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Medical and Biotech [MESH] Definitions

Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

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