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Extent of Surgical Trauma in Open and Laparoscopic Cholecystectomy

2014-08-27 03:15:35 | BioPortfolio

Summary

The aim of this work is to evaluate which of the two types of operation (traditional/open and laparoscopic) has more impact on patients who were operated electively due to their chronic calculous cholecystitis.

Description

The prospective, single center, randomized study includes 120 patients who are operated electively - 60 patients operated laparoscopically and 60 patients operated traditionally. Biohumoral and endocrine parameters of response to trauma are determined from 24 hour urine and blood: adrenalin, noradrenalin, metabolites of corticosteroid hormone - 17- hydroxyl and 17- keto steroid (HPLC method), C reactive protein and albumin, glycemia, creatine phosphokinase, lactate dehydrogenase, sedimentation of erythrocytes and serum concentration of potassium.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Chronic Calculous Cholecystitis

Intervention

Laparoscopic cholecystectomy, Open Surgery

Location

Ministry of Health
Podgorica
Montenegro
81000

Status

Completed

Source

Ministry of Health, Montenegro

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:35-0400

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PubMed Articles [19432 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Procedures that avoid use of open invasive surgery in favor of closed or local surgery. These generally involve use of laparoscopic devices and remote-control manipulation of instruments with indirect observation of the surgical field through an endoscope or similar device. With the reduced trauma associated with minimally invasive surgery, long hospital stays may be reduced with increased rates of short stay or day surgery.

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Changing an operative procedure from an endoscopic surgical procedure to an open approach during the INTRAOPERATIVE PERIOD.

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