Trial for the Optimal Timing of HIV Therapy After Cryptococcal Meningitis

2014-07-24 14:07:22 | BioPortfolio


To determine after cryptococcal meningitis (CM) whether early initiation of antiretroviral therapy (ART) prior to hospital discharge results in superior survival compared to standard initiation of ART started as an outpatient.


After 7-10 days of amphotericin B therapy, subjects will be randomized in a 1:1 allocation to:

- Early initiation of ART (Experimental Group) = ART initiated within 72 hours after study entry, OR

- Standard initiation of ART (Control Group) = ART at >4 weeks after study entry

HIV therapy will be per national, in-country (Uganda) guidelines and at the discretion of the treating physician. Cryptococcal meningitis treatment will be using an amphotericin B based regimen per the national standard of care with additional safety monitoring.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment


Cryptococcal Meningitis


Early HIV Therapy Initiation, Standard HIV Therapy Initiation


Mulago Naitonal Hospital


Not yet recruiting


University of Minnesota - Clinical and Translational Science Institute

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:07:22-0400

Clinical Trials [3980 Associated Clinical Trials listed on BioPortfolio]

Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa

Cryptococcal Meningitis continues to be one of the most devastating AIDS defining illness in sub-Saharan Africa. Despite the availability of azoles such as fluconazole for treatment, mort...

Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis

The goal of this randomized clinical trial is to compare early versus standard timing of initiation of antiretroviral therapy (ART) with respect to clearance of Cryptococcus neoformans fro...

Multi-Center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis

To compare the safety and effectiveness of fluconazole (FCZ) and amphotericin B (AMB), alone or in combination with flucytosine (FLC), as treatment for acute cryptococcal meningitis in pat...

Early Initiation of HAART

This study proposes to evaluate a pre-DHHS guideline of HAART initiation and then de-intensification management strategy in adolescents with mild immunosuppression and compare changes in C...

Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screeining in AIDS

The aim of the study is to evaluate systematic pre-antiretroviral cryptococcal antigen screening and pre-emptive fluconazole therapy in antigen positive patients, as a strategy to reduce m...

PubMed Articles [22426 Associated PubMed Articles listed on BioPortfolio]

Treatment for HIV-associated cryptococcal meningitis.

Cryptococcal meningitis is a severe fungal infection that occurs primarily in the setting of advanced immunodeficiency and remains a major cause of HIV-related deaths worldwide. The best induction the...

Arachnoid diverticulum diagnosis following treatment of cryptococcal meningitis in a dog.

Successful long-term treatment of cryptococcal meningitis in dogs is clinically challenging. In humans, there are only rare case reports of complications post-treatment including arachnoid diverticula...

Early Initiation of Tumor Necrosis Factor Antagonist-based Therapy for Patients with Crohn's Disease Reduces Costs Compared With Late Initiation.

Antagonists of tumor necrosis factor (TNF) are effective for induction and maintenance of remission of Crohn's disease (CD) and are generally prescribed when patients do not respond to conventional, l...

Effect of point-of-care early infant diagnosis on antiretroviral therapy initiation and retention of patients: a cluster-randomised trial.

We measured the effect of point-of-care early infant HIV testing on antiretroviral therapy initiation rates and retention in care among infants in Mozambique.

Immediate Physical Therapy Initiation in Patients With Acute Low Back Pain Is Associated With a Reduction in Downstream Health Care Utilization and Costs.

Physical therapy is an important treatment option for patients with low back pain (LBP). However, whether to refer patients for physical therapy and the timing of initiation remain controversial.

Medical and Biotech [MESH] Definitions

A eukaryotic initiation factor that binds to 40S ribosomal subunits. Although initially considered a "non-essential" factor for eukaryotic transcription initiation, eukaryotic initiation factor-1 is now thought to play an important role in localizing RIBOSOMES at the initiation codon of MRNA.

A component of eukaryotic initiation factor-4F that is involved in multiple protein interactions at the site of translation initiation. Thus it may serve a role in bringing together various initiation factors at the site of translation initiation.

A trimeric peptide initiation factor complex that associates with the 5' MRNA cap structure of RNA (RNA CAPS) and plays an essential role in MRNA TRANSLATION. It is composed of EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; and EUKARYOTIC INITIATION FACTOR-4G.

A eukaryotic initiation factor that interacts with the 40S initiation complex and promotes the hydrolysis of the bound GTP. The hydrolysis of GTP causes the release of EUKARYOTIC INITIATION FACTOR-2 and EUKARYOTIC INITIATION FACTOR-3 from the 40S subunit and the subsequent joining of the 60S ribosomal subunit to the 40S complex to form the functional 80S initiation complex

A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.

More From BioPortfolio on "Trial for the Optimal Timing of HIV Therapy After Cryptococcal Meningitis"

Quick Search


Relevant Topic

AIDS; Acquired Immune Deficiency Syndrome. HIV; Human Immunodeficiency Virus HIV infection causes AIDS. HIV infection also causes the production of anti-HIV antibodies, which forms the test for HIV in patients. People who have the HIV antibodies are ...

Searches Linking to this Trial