Predictors of Rates of Resistant Gram-Negative Bacteria

2014-07-24 14:07:23 | BioPortfolio


Antibiotic resistance in gram-negative bacteria continues to increase in US hospitals. This comes at a time when there are few new drugs in development that are active for these resistant organisms. The implication is that we must learn to use the drugs that we have more wisely and develop new strategies that will preserve existing agents. Antimicrobial "stewardship" programs are one strategy that many hospitals are adopting to improve the quality of antimicrobial use. The goal of this project is to develop a consortium of US academic medical centers that will allow characterization of the relationships between antibiotic use and rates of resistance for gram-negative pathogens, and to help hospital devise new strategies that will modify antibiotic use and possibly delay or reduce resistance.

The specific hypotheses are:

- Hospitals with established or emerging resistance in gram-negative pathogens, including extended spectrum beta-lactamase (ESBL) producing organisms, carbapenem-resistant enterobacteriaceae (CRE)and carbapenem-resistant P. aeruginosa have a different pattern of antimicrobial drug use compared to hospitals with fewer of these organisms.

- Hospital use of ertapenem is not associated with the rates of carbapenem-resistant organisms.

Study Design

Observational Model: Ecologic or Community, Time Perspective: Retrospective




Virginia Commonwealth University
United States


Active, not recruiting


Virginia Commonwealth University

Results (where available)

View Results


Published on BioPortfolio: 2014-07-24T14:07:23-0400

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