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Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)

2014-08-27 03:15:43 | BioPortfolio

Summary

The proposed pilot project for this seed grant focuses on the role of intestinal serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS). In this study we will further assess serine-protease activity in patients with D-IBS and also explore a possible mechanism by which these proteases can lead to alterations in intestinal physiology and symptoms in these patients.

The general hypotheses for the proposed research are that (A) the levels of fecal serine-protease in patients with D-IBS are abnormally increased (B) this abnormal serine-protease activity leads to/is associated with an abnormal increase in intestinal permeability and therefore enables (C) chronic stimulation and activation of the mucosal immune system in these patients. In addition, it is aim to determine whither periodontal inflammation is associated with intestinal permeability and serine protease activity.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Colon, Irritable

Location

University of North Carolina at Chapel Hill, Program in Digestive Health and the Department of Gastroenterology and Hepatology
Chapel Hill
North Carolina
United States
27599-7080

Status

Recruiting

Source

University of North Carolina, Chapel Hill

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:43-0400

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Medical and Biotech [MESH] Definitions

The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.

The segment of LARGE INTESTINE between ASCENDING COLON and DESCENDING COLON. It passes from the RIGHT COLIC FLEXURE across the ABDOMEN, then turns sharply at the left colonic flexure into the descending colon.

The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.

A segment of the COLON between the RECTUM and the descending colon.

Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)

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