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Safety and Efficacy of Bevacizumab in High-Risk Corneal Transplant Survival

2014-08-27 03:15:47 | BioPortfolio

Summary

The leading risk factor for corneal transplant rejection is abnormal blood vessel growth of the host bed. Vascular endothelial growth factor (VEGF) is thought to be a mediator of this corneal neovascularization, therefore we would like to test the safety and efficacy of local VEGF blockade in the promotion of graft survival in high risk corneal transplants.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Conditions

Corneal Neovascularization

Intervention

Avastin (bevacizumab), 0.9% NaCl

Location

Massachusetts Eye and Ear Infirmary
Boston
Massachusetts
United States
02114

Status

Recruiting

Source

Massachusetts Eye and Ear Infirmary

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:47-0400

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Medical and Biotech [MESH] Definitions

New blood vessels originating from the corneal veins and extending from the limbus into the adjacent CORNEAL STROMA. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as TRACHOMA, viral interstitial KERATITIS, microbial KERATOCONJUNCTIVITIS, and the immune response elicited by CORNEAL TRANSPLANTATION.

A TIE receptor tyrosine kinase that is found almost exclusively on ENDOTHELIAL CELLS. It is required for both normal embryonic vascular development (NEOVASCULARIZATION, PHYSIOLOGIC) and tumor angiogenesis (NEOVASCULARIZATION, PATHOLOGIC).

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Fibroblasts which occur in the CORNEAL STROMA.

A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.

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