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Extended Adjuvant Treatment With Letrozole in Breast Cancer Who Complete 5 Years of Toremifene

2014-08-27 03:15:47 | BioPortfolio

Summary

The purpose of this study is to assess Efficacy and Safety of Extended Adjuvant Treatment With Letrozole in Postmenopausal Women With Hormone Receptor Positive Breast Cancer Who Complete 5 Years of Toremifene

Description

1. Primary purpose To evaluate disease free survival rate (DFS) after taking 36 months with Letrozole in postmenopausal women with hormone receptor positive breast cancer who complete 5 years of Toremifene

2. Secondary purpose

- To evaluate follows after taking 36 months with Letrozole in postmenopausal women with hormone receptor positive breast cancer who complete 5 years of Toremifene.

1. Disease Free Survival rate(DFS)-12 months, 24 months

2. Distant disease free survival rate(DDFS), Overall Survival(OS)

- 12 months, 24 months, 36 months c. safety

- Change of lipid profiles

- Mortality and morbidity due to Cardiovascular disease

- Incidence of Fracture

- Change of Bone density

- Common toxic effect

Study Design

Control: Historical Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Breast Cancer

Intervention

Letrozole

Location

Department of Surgery, Asan medical center
Seoul
Korea, Republic of

Status

Enrolling by invitation

Source

Korean Breast Cancer Study Group

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:47-0400

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