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L-NMMA Dose-response Study in Healthy Subjects

2014-08-27 03:15:49 | BioPortfolio

Summary

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)

Conditions

Healthy

Intervention

NG-monomethyl-L-arginine (L-NMMA), NG-monomethyl-L-arginine (L-NMMA), NG-monomethyl-L-arginine (L-NMMA), Placebo

Location

Departments of Medical Research
Holstebro
Denmark
7500

Status

Completed

Source

Holstebro Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:49-0400

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Medical and Biotech [MESH] Definitions

An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.

A group of compounds that are monomethyl derivatives of pyridines. (From Dorland, 28th ed)

An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.

Enzymes that catalyze the methylation of arginine residues of proteins to yield N-mono- and N,N-dimethylarginine. This enzyme is found in many organs, primarily brain and spleen.

A derivative of complement C5a, generated when the carboxy-terminal ARGININE is removed by CARBOXYPEPTIDASE B present in normal human serum. C5a des-Arg shows complete loss of spasmogenic activity though it retains some chemotactic ability (CHEMOATTRACTANTS).

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