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L-NMMA Dose-response Study in Healthy Subjects

2014-08-27 03:15:49 | BioPortfolio

Summary

The purpose of this study is to investigate the effect of different levels of nitric oxide inhibition on blood pressure and arterial stiffness in healthy subjects. L-NMMA, an inhibitor of the nitric oxide synthase, is administered as bolus injection followed by continuous infusion, and is expected to raise blood pressure and arterial stiffness according to L-NMMA dose.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)

Conditions

Healthy

Intervention

NG-monomethyl-L-arginine (L-NMMA), NG-monomethyl-L-arginine (L-NMMA), NG-monomethyl-L-arginine (L-NMMA), Placebo

Location

Departments of Medical Research
Holstebro
Denmark
7500

Status

Completed

Source

Holstebro Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:49-0400

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Medical and Biotech [MESH] Definitions

An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.

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