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Inflammatory Effects of a Lung Recruitment Manoeuvre

2014-07-24 14:09:58 | BioPortfolio

Summary

Recruitment manoeuvres, consisting of sustained inflations at high airway pressures, have been advocated as an adjunct to mechanical ventilation in lung protective ventilation strategies to prevent the collapse of the lung.

This study aims to determine the safety and efficacy of a recruitment manoeuvre, by considering its impact on gas exchange, hemodynamics and on the release of systemic inflammatory mediators.

Description

This prospective study will analyse the effects of a single recruitment manoeuvre in critically ill patients. Subjects will be mechanically ventilated patients needing alveolar RMs. After a period of stable lung protective approach ventilation, they will receive the "40/30" RM; lung mechanics, gas exchange, hemodynamics and plasmatic concentration of inflammatory mediators will be obtained before and after the RM. An ultrasound score, established from the lung aeration status of upper and lower parts of anterior and lateral chest wall, will also be calculated before and after the manoeuvre.In selected patients cytokine release in the bronchoalveolar lavage will be measured as well.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Respiratory Insufficiency

Intervention

40/30 recruitment manoeuvre, continuous positive airway pressure (CPAP)

Location

U.O. Anestesia e Rianimazione IV, Azienda Ospedaliero Universitaria Pisana
Pisa
Italy
56126

Status

Recruiting

Source

Azienda Ospedaliero, Universitaria Pisana

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:09:58-0400

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