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Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)

2014-07-23 21:10:26 | BioPortfolio

Summary

Sildenafil is efficacious in newborns with persistent pulmonary hypertension and its use will reduce the need for inhaled nitric oxide.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

PPHN

Intervention

sildanefil

Status

Not yet recruiting

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:10:26-0400

Clinical Trials [7 Associated Clinical Trials listed on BioPortfolio]

N-Terminal Pro-Brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension

Babies who are suspected of having persistent pulmonary hypertension (PPHN) will be included in this study. PPHN is a condition in which the blood is restricted from flowing to the lungs ...

Milrinone in Congenital Diaphragmatic Hernia

Infants with congenital diaphragmatic hernia (CDH) usually have pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN) leading to hypoxemic respiratory failure (H...

Study Protocol Evaluating Transient Tachypnoea of the Newborn in Term and Near Term Neonates

Transient tachypnoea of the newborn (TTN) is a common cause of hospitalisation in the neonatal period, complicating 1 to 1,5 per cent life birth. Predisposing factors are prematurity, birt...

Epidemiology of Persistent Pulmonary Hypertension of the Newborn - SCOR in Lung Biology and Diseases in Infants and Children

To conduct an epidemiologic study of persistent pulmonary hypertension of the newborn ( PPHN) infant.

Study on the Use of Inhaled NO (iNO)

This is a prospective, observational, multicenter study conducted during 1 year in adult and paediatric intensive care units equipped with the EZ-KINOX™ system. A maximum of 250 patient...

PubMed Articles [8 Associated PubMed Articles listed on BioPortfolio]

Persistent pulmonary hypertension of the newborn after fetomaternal hemorrhage.

Newborns with anemia are at increased risk of persistent pulmonary hypertension of the newborn (PPHN), yet reports on the association between fetomaternal hemorrhage (FMH) and PPHN are rare. To optimi...

The Practical Challenges of Diagnosis and Treatment Options in Persistent Pulmonary Hypertension of the Newborn: A Developing Country's Perspective.

Persistent pulmonary hypertension of the newborn (PPHN) is a complication of several respiratory diseases characterized by an elevation in pulmonary vascular resistance with resultant right-to-left sh...

Persistent pulmonary hypertension alters epigenetic characteristics of endothelial nitric oxide synthase gene in a fetal lamb model.

Decreased expression of endothelial nitric oxide synthase (eNOS), a key mediator of perinatal transition, characterizes persistent pulmonary hypertension of the newborn (PPHN) in neonates and a fetal ...

Inhaled Epoprostenol for Pulmonary Hypertension Treatment in Neonates: A 12-Year Experience.

 Persistent pulmonary hypertension of the newborn (PPHN) occurs in 10% of neonatal respiratory insufficiency. To selectively reduce pulmonary vascular resistance, several treatments have been tried....

Prenatal Exposure to SSRIs and SNRIs and Risk for Persistent Pulmonary Hypertension of The Newborn: A Systematic Review, Meta-Analysis and Network Meta-Analysis.

There is a marked increase in the use of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) in the last decade. Many newborns are likely to be exp...

Medical and Biotech [MESH] Definitions

None available.

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