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The purpose of this trial is to determine the safety and efficacy of CVac compared with Standard of Care in ovarian cancer patients who are in remission after first or second-line therapy.
- To confirm the safety of administering CVac in this population.
- To determine the effects of CVac on progression-free survival (PFS).
- To determine overall survival (OS) for recurrent ovarian cancer patients who receive CVac after achieving remission in the first or second-line setting.
- Evaluation of host immunologic response to CVac administration.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Epithelial Ovarian Cancer
MUC1 Dendritic Cell Vaccine (CVac)
California Cancer Care, Inc.
Prima BioMed Ltd
Published on BioPortfolio: 2014-08-27T03:15:55-0400
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A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
A suspension of killed Bordetella pertussis organisms, used for immunization against pertussis (WHOOPING COUGH). It is generally used in a mixture with diphtheria and tetanus toxoids (DTP). There is an acellular pertussis vaccine prepared from the purified antigenic components of Bordetella pertussis, which causes fewer adverse reactions than whole-cell vaccine and, like the whole-cell vaccine, is generally used in a mixture with diphtheria and tetanus toxoids. (From Dorland, 28th ed)
A superficial, epithelial Herpesvirus hominis infection of the cornea, characterized by the presence of small vesicles which may break down and coalesce to form dendritic ulcers (KERATITIS, DENDRITIC). (Dictionary of Visual Science, 3d ed)
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