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Safety and Tolerability of Etanercept in Alzheimer's Disease

2014-08-27 03:15:55 | BioPortfolio

Summary

The primary aim of the study is to determine the safety and tolerability of etanercept in subjects with Alzheimer's Disease. The effects of etanercept on cognitive, behavioural, functional and immunological outcomes will be examined as secondary aims.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Alzheimer's Disease

Intervention

Etanercept, Placebo

Location

Memory Assessment and Research Centre, Moorgreen Hospital
Southampton
Hampshire
United Kingdom
SO30 3JB

Status

Not yet recruiting

Source

University of Southampton

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:15:55-0400

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Abnormal structures located chiefly in distal dendrites and, along with NEUROFIBRILLARY TANGLES and SENILE PLAQUES, constitute the three morphological hallmarks of ALZHEIMER DISEASE. Neuropil threads are made up of straight and paired helical filaments which consist of abnormally phosphorylated microtubule-associated tau proteins. It has been suggested that the threads have a major role in the cognitive impairment seen in Alzheimer disease.

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