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Efficacy and Safety Study of Bevacizumab, Capecitabine and Oxaliplatin, to Treat Elderly Patients With Metastatic Colorectal Adenocarcinoma

2014-08-27 03:16:00 | BioPortfolio

Summary

The purpose of this study is to determine whether bevacizumab, capecitabine and oxaliplatin are an effective and safe first line of treatment for elderly patients with metastatic colorectal adenocarcinoma.

Description

The efficacy will be determined by objective response rate following RECIST criteria.

In several clinical trials with Bevacizumab, there has been demonstrated that elderly patients benefits as well as the younger of a combination therapy with chemotherapy plus Bevacizumab, but these results have come from subgroup analyses of trials not specifically design to test the effect of these combinations on the elderly. This clinical trial is specific only for elderly patients and we expect to confirm the benefits demosntrated in other clinical trials where the elderly patients were a number reduced.

Study Design

Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Metastatic Colorectal Cancer

Intervention

bevacizumab, capecitabine, oxaliplatin

Location

Hospital de L´Hospitalet
Hospitalet de Llobregat
Barcelona
Spain
08906

Status

Recruiting

Source

Grupo Espanol Multidisciplinario del Cancer Digestivo

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:00-0400

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A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.

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