Comparison of Two Doses of Intranasal Dexmedetomidine as Premedication in Children

2014-08-27 03:16:01 | BioPortfolio


Intranasal dexmedetomidine has shown to be an effective sedative when used prior to anaesthetic induction as premedication. 1mcg/kg intranasal dexmedetomidine was used in previous study and it produced satisfactory sedation in more than 50% of the children at the time of anaesthetic induction with no adverse effect. In this study we aim to compare 1mcg/kg with 2mcg/kg intranasal dexmedetomidine in children. We expect more children would attain satisfactory sedation prior to anaesthetic induction when higher dose is used.

Study Design

Allocation: Randomized, Control: Dose Comparison, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital




QUeen Mary Hospital
Hong Kong
Hong Kong




The University of Hong Kong

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:01-0400

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Medical and Biotech [MESH] Definitions

Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.

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