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Effect of Nortriptyline in Cortical Representation of Heartburn in Nonerosive Reflux Disease (NERD) Patients

2014-08-27 03:16:01 | BioPortfolio

Summary

Patients with nonerosive reflux disease (NERD) are less responsive to standard treatment with proton pump inhibitors. The hypothesis of this study was that nortriptyline in analgesic doses may decrease heartburn perception and its corresponding cortical activity measured by magnetic resonance image. Therefore, the aim of this study was to assess the cortical representation of heartburn in patients with NERD under treatment with nortriptyline and placebo.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Gastroesophageal Reflux Disease

Intervention

Nortriptyline, Placebo arm

Location

Kozma
Passo Fundo
RS
Brazil
990010-080

Status

Enrolling by invitation

Source

Universidade de Passo Fundo

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:01-0400

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