Extubation Readiness and Neuroventilatory Efficiency After Acute Respiratory Failure

2014-08-27 03:16:02 | BioPortfolio


The aim of this study was to compare the indices of rapid shallow breathing, NME(neuromechanical efficiency), and NVE neuroventilatory efficiency)between patients being successfully extubated and those who failed weaning.


Patients, mechanically ventilated for > 24 h, were included when they met criteria for their first SBT on CPAP (5-6 cmH2O) for 30 minutes. Patients who did not fulfill the criteria for successful SBT, or required assist, or deceased within 48h post-extubation were considered extubation failure (F). Patients who completed the SBT and remained extubated > 48 h were considered successfully extubated (S). Before and during the SBT, arterial blood gases, heart, rate, blood pressure, and EAdi, flow, Vt, f, and, airway pressure (Paw) were measured. At 0, 5, 10, 15 and 30 minutes of the SBT, f/Vt, NME, and NVE were calculated. NME was calculated as Paw/EAdi during inspiratory occlusion. NVE was calculated as Vt/EAdi during unassisted inspirations.Arterial blood gases, heart rate, and blood pressure were measured. The receiver operating characteristic (ROC) curve was calculated to evaluate the predictive performance of each index.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Respiration, Artificial


Nanjing Zhong-Da Hospital




Southeast University, China

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:02-0400

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Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).

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