Advertisement

Topics

Artemether-Lumefantrine (AL) Unit Dose Pre-packs Versus Blister Packs

2014-08-27 03:16:02 | BioPortfolio

Summary

The purpose of this study is to determine if adherence and effectiveness of AL in the treatment of uncomplicated malaria in children aged under five years using blister packs with pictorial leaflets can be at levels comparable to those with unit dosed age specific pre-packs.

Description

Prompt and adequate treatment of clinical malaria episodes remains one of the key elements of malaria control and this partly depends on patients' compliance to treatment. Uganda adopted Artemether-Lumefantrine (AL) as first line treatment for uncomplicated malaria. This is available at the health facilities in form of 6 dose pre-packs with different doze strengths in different packages. However, concerns about the costs and stock-outs of these packages have been raised and alternative equally efficacious alternatives need to be determined in order to reduce these problems. This study will assess if AL blister-packs can act as alternatives to the unit dose age specific pre-packs in the public sector

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Malaria

Intervention

AL Blister-packs with Instruction leaflets, AL unit dose age specific pre-packs

Location

Mulanda Health centre IV
Tororo District
Uganda
256

Status

Recruiting

Source

Malaria Consortium, Uganda

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:02-0400

Clinical Trials [502 Associated Clinical Trials listed on BioPortfolio]

Blister Packaging Medication to Increase Treatment Adherence and Clinical Response

This quantitative, interview-based study will determine if increased prescription medication adherence via blister pack administration will reduce suicide related behavior among the high r...

The Short Term Effect of Hot Packs and Whirlpool for Increasing Total Active Motion at the Wrist

This study investigates the effect of hot packs versus whirlpool and exercise for patients with distal radius fracture (DRF). Patients with recently healed DRF are randomized into two grou...

Analysis of the Effects on Human Tissues After Application of Therapeutic Modalities.

As a therapeutic modality, cryotherapy is highly used for soft tissue damage control during acute and subacute stages. Cryotherapy is able to reduce pain, inflammatory condition, muscle sp...

Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers

The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after b...

Reading Problems in Children Living in Urban Areas

The first line of defense against reading disabilities is good classroom reading instruction. This study describes how characteristics of students, teachers, and instruction relate to aca...

PubMed Articles [13098 Associated PubMed Articles listed on BioPortfolio]

Feature instructions improve face-matching accuracy.

Identity comparisons of photographs of unfamiliar faces are prone to error but important for applied settings, such as person identification at passport control. Finding techniques to improve face-mat...

Peer instruction in a physiology laboratory course in China.

Peer instruction has been used extensively in lecture courses; however, there is little evidence of its use in laboratory courses. The purpose of the present study was to describe the implementation o...

Current trends in the surgical management of blister aneurysms. An illustrative case series.

Blister aneurysms are rare lesions characterized by a bleb-like appearance in combination with prominent fragility. They mainly affect the supraclinoid internal carotid artery and they are often thoug...

Draft genomes of two blister beetles (genus: Hycleus) harvested for the potent blistering agent cantharidin.

Commonly known as blister beetles or Spanish fly, there are more than 1,500 species in the Meloidae family (Hexapoda: Coleoptera: Tenebrionoidea) that produce the potent defensive blistering agent can...

Spontaneous Healing of a Ruptured Blood Blister-like Aneurysm: Case Report.

Blood blister-like aneurysms (BBAs) are an uncommon group of arterial aneurysms with a high risk of rupture, progression, and re-rupture. The best intervention is unclear, but their clinical behavior ...

Medical and Biotech [MESH] Definitions

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).

The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

A treatment schedule in which the total dose of radiation is divided into large doses.

More From BioPortfolio on "Artemether-Lumefantrine (AL) Unit Dose Pre-packs Versus Blister Packs"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Malaria
Malaria is a serious tropical disease spread by mosquitoes. If malaria is not diagnosed and treated promptly, it can be fatal. What causes malaria? Malaria is caused by a type of parasite known as Plasmodium. There are many different types of Plasmod...

Pediatrics
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Infectious-diseases
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...


Searches Linking to this Trial