Artemether-Lumefantrine (AL) Unit Dose Pre-packs Versus Blister Packs

2014-08-27 03:16:02 | BioPortfolio


The purpose of this study is to determine if adherence and effectiveness of AL in the treatment of uncomplicated malaria in children aged under five years using blister packs with pictorial leaflets can be at levels comparable to those with unit dosed age specific pre-packs.


Prompt and adequate treatment of clinical malaria episodes remains one of the key elements of malaria control and this partly depends on patients' compliance to treatment. Uganda adopted Artemether-Lumefantrine (AL) as first line treatment for uncomplicated malaria. This is available at the health facilities in form of 6 dose pre-packs with different doze strengths in different packages. However, concerns about the costs and stock-outs of these packages have been raised and alternative equally efficacious alternatives need to be determined in order to reduce these problems. This study will assess if AL blister-packs can act as alternatives to the unit dose age specific pre-packs in the public sector

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Bio-equivalence Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment




AL Blister-packs with Instruction leaflets, AL unit dose age specific pre-packs


Mulanda Health centre IV
Tororo District




Malaria Consortium, Uganda

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:02-0400

Clinical Trials [530 Associated Clinical Trials listed on BioPortfolio]

Blister Packaging Medication to Increase Treatment Adherence and Clinical Response

This quantitative, interview-based study will determine if increased prescription medication adherence via blister pack administration will reduce suicide related behavior among the high r...

The Short Term Effect of Hot Packs and Whirlpool for Increasing Total Active Motion at the Wrist

This study investigates the effect of hot packs versus whirlpool and exercise for patients with distal radius fracture (DRF). Patients with recently healed DRF are randomized into two grou...

An Open Label Trial Examining Web Based Colonoscopy Preparation Instruction

Current pre-colonoscopy instructions are given to patients in the form of a written or printed instruction set. We have developed a web-based instruction system which aims to provide a mor...

Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers

The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after b...

Analysis of the Effects on Human Tissues After Application of Therapeutic Modalities.

As a therapeutic modality, cryotherapy is highly used for soft tissue damage control during acute and subacute stages. Cryotherapy is able to reduce pain, inflammatory condition, muscle sp...

PubMed Articles [13050 Associated PubMed Articles listed on BioPortfolio]

Effects of Instruction on Parent Competency During Infant Handling in a Neonatal Intensive Care Unit.

The primary purpose of this study was to investigate the effectiveness of 3 different methods for delivering instruction on infant handling to parents in the neonatal intensive care unit (NICU).

Survey of outpatients' use and needs of patient medicine information leaflets in Thailand.

Background Patient information leaflets are important sources of medicine information. Regulations of patient information leaflet provision varies among country. Little is known regarding patients' be...

Perspective Effects on Recall in a Testimony Paradigm.

The two present studies examined the influence of perspective instructions given during encoding and retrieval on the recall of a visual event. Participants viewed slides or a film depicting a day in ...

Do One Then See One: Sequencing Discovery Learning and Direct Instruction for Simulation-Based Technical Skills Training.

When teaching technical skills, educators often include a mix of learner self-regulation and direct instruction. Appropriate sequencing of these activities-such as allowing learners a period of discov...

Peer instruction in a physiology laboratory course in China.

Peer instruction has been used extensively in lecture courses; however, there is little evidence of its use in laboratory courses. The purpose of the present study was to describe the implementation o...

Medical and Biotech [MESH] Definitions

A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.

The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.

The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).

The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.

A treatment schedule in which the total dose of radiation is divided into large doses.

More From BioPortfolio on "Artemether-Lumefantrine (AL) Unit Dose Pre-packs Versus Blister Packs"

Quick Search


Relevant Topics

Malaria is a serious tropical disease spread by mosquitoes. If malaria is not diagnosed and treated promptly, it can be fatal. What causes malaria? Malaria is caused by a type of parasite known as Plasmodium. There are many different types of Plasmod...

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...

Searches Linking to this Trial