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A Study To Explore The Effect On Inflammatory Markers After Nasal Allergen Challenge In Subjects With Seasonal Allergic Rhinitis And The Effect Of A Single Dose Of Ibuprofen Or Fluticasone Propionate On The Allergen Response.

2014-08-27 03:16:03 | BioPortfolio

Summary

After a nasal allergen challenge it should be possible to measure markers of inflammation that may be useful to assess the properties of future drugs. If these markers are reproducible and impacted by the study drugs they could be useful for future drug development.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Allergic Rhinitis

Intervention

Ibuprofen, Fluticasone propionate, Placebo

Location

Pfizer Investigational Site
Omaha
Nebraska
United States
68131

Status

Completed

Source

Pfizer

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:03-0400

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PubMed Articles [1703 Associated PubMed Articles listed on BioPortfolio]

Onset of action of the fixed combination intranasal azelastine-fluticasone propionate in an allergen exposure chamber.

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Medical and Biotech [MESH] Definitions

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A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.

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