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Re-STOP DVT: Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users

2014-08-27 03:16:08 | BioPortfolio

Summary

Reload of high dose statin may have potential for preventing deep vein thrombosis (DVT) in patients on statin undergoing total knee replacement arthroplasty.

A body of evidence have been reported that reloading of atorvastatin have efficacy in reducing periprocedural myocardial infarction and contrast induced nephropathy. These effects are considered to be mainly due to their antioxidant anti-thrombotic and anti-inflammatory property.

We, therefore, hypothesize that high dose atorvastatin re-loading may prevent DVT.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Conditions

Thrombosis

Intervention

High dose Atorvastatin+enoxaparin, Enoxaparin

Location

Hallym University Sacred Heart Hospital, Department of Cardiology and Orthopedic Surgery
Anyang-si
Gyeonggi-do
Korea, Republic of
431-070

Status

Recruiting

Source

Hallym University Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:08-0400

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