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NAC as a Potential Treatment for Methamphetamine Dependence

2014-08-27 03:16:08 | BioPortfolio

Summary

Methamphetamine is a potent, highly addictive psychostimulant that produces psychomotor activation and euphoria (Ellinwood and Cohen 1971; Martin et al 1971). The abuse of MA is rapidly becoming both a national and a global epidemic (SAMHSA 2007), as the drug is illicitly manufactured on a large scale by criminal cartels using relatively inexpensive ingredients. Current treatments for MA dependence consist primarily of psychosocial and rehabilitation approaches, which have limited long-term success (Rawson et al 2004). The identification of effective medication treatments is an extremely high priority.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Conditions

Methamphetamine Addiction

Intervention

Placebo (Solution without NAC), N-acetylcysteine, N-Acetylcysteine

Location

Michael E. DeBakey VA Medical Center
Houston
Texas
United States
77030

Status

Not yet recruiting

Source

National Institute on Drug Abuse (NIDA)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:08-0400

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PubMed Articles [5174 Associated PubMed Articles listed on BioPortfolio]

The effect of N-acetylcysteine or bupropion on methamphetamine self-administration and methamphetamine-triggered reinstatement of female rats.

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To understand the underlying cellular mechanisms during inactivation of Escherichia coli in response to antimicrobial solution of nonthermal plasma-activated N-acetylcysteine (NAC).

Evaluation of the warming sensation, acceptability, and local tolerability of an acetylcysteine oral solution containing the flavoring agent IFF flavor 316282 in the treatment of productive cough
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This open-label study sought to evaluate the warming sensation produced by IFF flavor 316282 in an acetylcysteine oral solution in subjects with productive cough.

Trichotillomania: a good response to treatment with N-acetylcysteine.

Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to...

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Medical and Biotech [MESH] Definitions

The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).

The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.

Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.

The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.

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