NAC as a Potential Treatment for Methamphetamine Dependence
Summary
Methamphetamine is a potent, highly addictive psychostimulant that produces psychomotor activation and euphoria (Ellinwood and Cohen 1971; Martin et al 1971). The abuse of MA is rapidly becoming both a national and a global epidemic (SAMHSA 2007), as the drug is illicitly manufactured on a large scale by criminal cartels using relatively inexpensive ingredients. Current treatments for MA dependence consist primarily of psychosocial and rehabilitation approaches, which have limited long-term success (Rawson et al 2004). The identification of effective medication treatments is an extremely high priority.
Study Design
Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
Conditions
Methamphetamine Addiction
Intervention
Placebo (Solution without NAC), N-acetylcysteine, N-Acetylcysteine
Location
Michael E. DeBakey VA Medical Center
Houston
Texas
United States
77030
Status
Not yet recruiting
Source
National Institute on Drug Abuse (NIDA)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT01063205
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-08-27T03:16:08-0400
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Medical and Biotech [MESH] Definitions
Acetylcysteine
The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
Saline Solution, Hypertonic
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
Osmotic Pressure
The pressure required to prevent the passage of solvent through a semipermeable membrane that separates a pure solvent from a solution of the solvent and solute or that separates different concentrations of a solution. It is proportional to the osmolality of the solution.
Glucose Solution, Hypertonic
Solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.
Vaginal Douching
The washing of the VAGINA cavity or surface with a solution. Agents or drugs can be added to the irrigation solution.
