NAC as a Potential Treatment for Methamphetamine Dependence

2014-08-27 03:16:08 | BioPortfolio


Methamphetamine is a potent, highly addictive psychostimulant that produces psychomotor activation and euphoria (Ellinwood and Cohen 1971; Martin et al 1971). The abuse of MA is rapidly becoming both a national and a global epidemic (SAMHSA 2007), as the drug is illicitly manufactured on a large scale by criminal cartels using relatively inexpensive ingredients. Current treatments for MA dependence consist primarily of psychosocial and rehabilitation approaches, which have limited long-term success (Rawson et al 2004). The identification of effective medication treatments is an extremely high priority.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment


Methamphetamine Addiction


Placebo (Solution without NAC), N-acetylcysteine, N-Acetylcysteine


Michael E. DeBakey VA Medical Center
United States


Not yet recruiting


National Institute on Drug Abuse (NIDA)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:08-0400

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Medical and Biotech [MESH] Definitions

The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.

Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).

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