The Adrenal Contribution to Androgen Production in Girls During Puberty

2014-08-27 03:16:08 | BioPortfolio


In girls with elevated androgens the precise source of androgen excess throughout puberty and early adolescence has not been carefully examined. The investigators propose to examine whether the adrenal gland produces the majority of androgens during puberty by studying the differences in androgen responses to Adrenocorticotropin hormone (ACTH) administration in normal weight (NW) and obese (OB) girls ages 7-18. The investigators' analyses will compare steroid changes before, 30 min, and 60 min after ACTH administration in NW and OB girls.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic




Cosyntropin 0.25 mg


University of california, san diego
La Jolla
United States




University of California, San Diego

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:16:08-0400

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Medical and Biotech [MESH] Definitions

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.

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A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.

Morphological and physiological development of FETUSES.

Morphological and physiological development of EMBRYOS.

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