Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen

2010-07-15 17:00:00 | BioPortfolio


The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment


Oral Lichen Planus




Hospital Avicenne-APHP




University Hospital, Tours

Results (where available)

View Results


Published on BioPortfolio: 2010-07-15T17:00:00-0400

Clinical Trials [1913 Associated Clinical Trials listed on BioPortfolio]

Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus

Is topical application of green tea polyphenols buccal tablet more effective in treatment of patients with symptomatic oral lichen planus in comparison with topical application of corticos...

Management of Pain in Oral Lichen Planus

Treating Oral Lichen Planus (OLP) is a big challenge for clinicians. Despite numerous existing remedies, to date no effective cure has been found, which is mainly attributed to the lack of...

Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream

Background and hypothesis. Oral erosive lichen planus (OELP) is a severe form of mucosal lichen planus. Lesions often induce intense pain and limit feeding. Its course is chronic with flar...

Topical "Non-Aromatic Very Rich in Steranes" (NAVS) Naphthalan for the Treatment of Oral Mucosal Diseases

This study evaluates the effectiveness of topical NAVS naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Half of participants with OLP and RA...

Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus

Glucosamine (GlcN) is an N-deacetyl amino sugar derived from the complete hydrolysis of chitosan with recently reported immunoregulatory capacity and anti-inflammatory effect and was admin...

PubMed Articles [4687 Associated PubMed Articles listed on BioPortfolio]

Plantar ulcerative lichen planus: rapid improvement with a novel triple-therapy approach.

Ulcerative lichen planus (ULP) is a rare variant of lichen planus that is characterized by chronic, painful, and disabling ulcerations. Ulcerative lichen planus has been known to be resistant to many ...

Topical pimecrolimus versus betamethasone for oral lichen planus: a randomized clinical trial.

Oral lichen plans (OLP) is a potentially malignant inflammatory mucocutaneous disease. CD133 is an investigated surface marker for cancer stem-like cells (CSCs) that may be involved in tumor initiatio...

Comparative Effects of Topical 0.2% Sirolimus for Angiofibromas in Adults and Pediatric Patients with Tuberous Sclerosis Complex.

Recent reports have suggested that the topical formulation of sirolimus is effective in treating facial angiofibromas in tuberous sclerosis complex (TSC). Here, we determined the safety and efficacy o...

How general dentists could manage a patient with oral lichen planus.

The literature hardly contains information on how patients suffering from oral lichen planus could be managed by dentists.

A case of microcystic lymphatic malformation successfully treated with topical sirolimus.

Microcystic lymphatic malformation (MLM), also known as "lymphangioma circumscriptum," is a lymphatic malformation which may involve the skin and subcutaneous tissues. Progressive growth of lesions ma...

Medical and Biotech [MESH] Definitions

Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)

An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.

Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.

Therapy using oral or topical photosensitizing agents with subsequent exposure to light.

A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

More From BioPortfolio on "Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen"

Quick Search


Searches Linking to this Trial