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Efficacy of Topical Rapamycin to Treat Chronic Erosive Oral Lichen

2010-07-15 17:00:00 | BioPortfolio

Summary

The purpose of this study is to determine wether topical rapamycin is more efficient than topical steroids in the treatment of chronic erosive lichen planus.

Study Design

Allocation: Randomized, Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Oral Lichen Planus

Intervention

TOPICAL SIROLIMUS (RAPAMUNE*), TOPICAL BETHAMETHASONE 0.05%

Location

Hospital Avicenne-APHP
Bobigny
France
93009

Status

Recruiting

Source

University Hospital, Tours

Results (where available)

View Results

Links

Published on BioPortfolio: 2010-07-15T17:00:00-0400

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Medical and Biotech [MESH] Definitions

Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)

An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.

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A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

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