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Phase I Dose Escalation Trial Evaluating the Safety and Tolerability of AZD6244 Adn IMC-A12 in Subjects With Advanced Solid Malignancies

2014-08-27 03:16:09 | BioPortfolio

Summary

To determine the safety and tolerability of IMC-A12 in combination with AZD6244 and define the maximally tolerated dose for the combination; explore preliminary efficacy of the combination of IMC-A12 and AZD6244 in advanced solid tumors; correlate pharmacokinetics (PK) of the combination of IMC-A12 and AZD6244 to pharmacodynamic (PD) endpoints.

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Advanced Solid Malignancies

Intervention

AZD6244 and IMC-A12, AZD6244 and IMC-A12

Location

Sidney Kimmel Cancer Center @ Johns Hopkins
Baltimore
Maryland
United States
21231

Status

Recruiting

Source

Sidney Kimmel Comprehensive Cancer Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:09-0400

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