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Study of MOC31-PE in Antigen Positive Carcinomas

2014-08-27 03:16:10 | BioPortfolio

Summary

Immunotoxins (ITs), monoclonal antibodies conjugated to plant or bacterial toxins, have been extensively investigated for their possible use as anti-tumor agents although not in carcinoma patients with minimal residual disease. Various ITs have been tested in early clinical trials and recent studies demonstrate anti-tumor activity of IT treatment in patients with glioblastoma and different solid tumors. Systemic treatment with immunotoxins directed against carefully selected epithelial cell surface molecules may have a potential for eradicating also dormant metastatic tumor cells, as their action is independent of cell proliferation. The effector moieties of the IT used here, the Pseudomonas exotoxin A (PE), inhibits protein synthesis in eukaryotic cells by catalytic inactivation (ribosylation) of elongation factor 2 in the ribosome complex.

Study Design

N/A

Conditions

Carcinoma

Intervention

MOC31-PE

Location

The Norwegian Radium Hospital, Department of Clinical Cancer Research
Oslo
Norway
NO-0310

Status

Recruiting

Source

Rikshospitalet HF

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:10-0400

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