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RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
- Assess the efficacy of temsirolimus in patients with recurrent or persistent malignant mixed mesodermal and Mullerian tumors (carcinosarcoma) of the uterus.
- Assess the safety and tolerability of this drug in these patients.
- Evaluate the time to tumor progression in patients treated with this drug.
- Evaluate the progression-free survival (PFS) of patients treated with this drug.
- Evaluate the 6-month PFS rate in patients treated with this drug.
- Evaluate the duration of response in patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study therapy, patients are followed up periodically for up to 3 years.
Primary Purpose: Treatment
Tower Cancer Research Foundation
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:16:10-0400
Define the maximum tolerated dose and dose limiting side-effects of temsirolimus in combination wtih erlotinib in patients with resistant solid tumors
This is an open-label trial investigating the efficacy of temsirolimus in recurrent or refractory primary CNS lymphoma (PCNSL) after initial chemotherapy with a high-dose methotrexate cont...
This study will compare the effectiveness and safety of two different doses of temsirolimus (Torisel).
This study is being done to determine the highest safe dose of the combination of temsirolimus and axitinib; to learn the side effects when these drugs are given together; and to determine...
The goal of this Pilot-study is to evaluate the response of unselected MDS patients to temsirolimus a drug approved for the treatment of renal cell cancer. It is planned to give temsirolim...
Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of bisphosphonates (BPs) or other targeted agent therapies. MRONJ appears as exposed bone, pus, and swelling in the oral an...
In this work, we develop a systematic approach for applying pathway knowledge to a multivariate Gaussian mixture model for dissecting a heterogeneous cancer tissue. The downstream transcription factor...
Renal cell cancer (RCC) has become a prototype example of the extensive intra-tumor heterogeneity and clonal evolution of human cancers. However, there is little direct evidence on how the genetic het...
Endometriosis is a well‑known risk factor for ovarian cancer. The genetic changes that characterise endometriosis are poorly understood; however, the mechanistic target of rapamycin (mTOR) pathway i...
An experimental sarcoma of mice.
An experimental sarcoma of mice.
An experimental sarcoma of rats.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
A family of transforming proteins isolated from retroviruses such as MOUSE SARCOMA VIRUSES. They are viral-derived members of the raf-kinase family of serine-theonine kinases.
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...
Head and neck cancers
Cancer can occur in any of the tissues or organs in the head and neck. There are over 30 different places that cancer can develop in the head and neck area. Mouth cancers (oral cancers) - Mouth cancer can develop on the lip, the tongue, the floor...