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Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the Uterus

2014-08-27 03:16:10 | BioPortfolio

Summary

RATIONALE: Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

PURPOSE: This phase II trial is studying how well temsirolimus works in treating patients with recurrent or persistent cancer of the uterus.

Description

OBJECTIVES:

- Assess the efficacy of temsirolimus in patients with recurrent or persistent malignant mixed mesodermal and Mullerian tumors (carcinosarcoma) of the uterus.

- Assess the safety and tolerability of this drug in these patients.

- Evaluate the time to tumor progression in patients treated with this drug.

- Evaluate the progression-free survival (PFS) of patients treated with this drug.

- Evaluate the 6-month PFS rate in patients treated with this drug.

- Evaluate the duration of response in patients treated with this drug.

OUTLINE: This is a multicenter study.

Patients receive temsirolimus IV over 30 minutes on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up periodically for up to 3 years.

Study Design

Primary Purpose: Treatment

Conditions

Sarcoma

Intervention

temsirolimus

Location

Tower Cancer Research Foundation
Beverly Hills
California
United States
90211

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:10-0400

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Medical and Biotech [MESH] Definitions

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An experimental sarcoma of mice.

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