Advertisement

Topics

Effect of Dietary Fat When Eaten With Fructose Versus Glucose

2014-08-27 03:16:13 | BioPortfolio

Summary

This study is designed to test the effects on liver fat of varying fat intake in the presence of fructose or glucose. We hypothesize that higher dietary fat when eaten with fructose as compared to glucose will increase the amount of hepatic lipid as measured by magnetic resonance spectroscopy.

Description

After 2 screening visits including an exercise test, DEXA and CT scan, qualifiers begin a 7 day diet with 20% fat, 65% carbohydrate (with 20% glucose) and 15 % protein. Participants consume 2 meals per day at PBRC with lunch and weekend meals packed to go. Following a test day, participants are randomized to one of 3 diet assignments and then test again:

1)20% fat, 65% carbohydrate (with 20% glucose beverage), 15% protein 2)40% fat, 45% carbohydrate (with 20% glucose beverage), 15% protein 3)40% fat, 45% carbohydrate (with 20% fructose beverage), 15% protein On Day 7 and again 14 days later participants have labs, an oral Glucose tolerance test, hepatic and intramuscular lipid measures by MRS, vital signs and waist measurement.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Conditions

Body Weight Changes

Intervention

40% Fat Diet, 20% Fructose Beverage, 20% Glucose Beverage, 20% Glucose Beverage

Location

Pennintgon Biomedical Research Center
Baton Rouge
Louisiana
United States
70808

Status

Recruiting

Source

Pennington Biomedical Research Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:13-0400

Clinical Trials [3458 Associated Clinical Trials listed on BioPortfolio]

The Effect of Dairy and Non-dairy Alternatives on Satiety and Post-meal Glycemia in Healthy Young Adults

This study investigates the effects of commercially-available dairy (1% cow's milk and yogurt beverage) and non-dairy alternatives (almond and soy beverages) on satiety and post-meal blood...

Neurobehavioral Plasticity to Regular Sugar-Sweetened Beverage Intake: An fMRI Experiment

The proposed project will examine the strength, specificity and persistence of neurobehavioral adaptions that occur in the initial period of repeated consumption of a branded sugar sweeten...

Feasibility and Acceptability of a Beverage Intervention for Hispanic Adults

This study aims to 1) assess the feasibility and acceptability of a prescribed beverage intervention in 50 obese Hispanic adults ages 18-64 years over 6 weeks; and 2) assess preliminary ef...

The Effect of 3-Week Consumption of Soya Beverage Enriched With Plant Sterols on Serum LDL-C

This is a local, single-center, two-arm, randomized, double-blind, placebo-controlled clinical trial that examines the LDL-C-lowering effect of the consumption of a soya beverage enriched ...

Physiological Effect of Ataulfo Mango (Manguifera Indica) Beverage in Exercise

The aim of this study is to assess the antioxidant capacity of two mango base beverages (AM1, AM2), against exercise-induced oxidative stress.

PubMed Articles [9599 Associated PubMed Articles listed on BioPortfolio]

A Randomized, Controlled Trial Evaluating Polydextrose as a Fiber in a Wet and Dry Matrix on Glycemic Control.

Functional fibers can help Americans increase their fiber intake by incorporating extracted or synthesized fibers into food products. The United States Food and Drug Administration has recently propos...

Solid Phase Extraction of Large Volume of Water and Beverage Samples to Improve Detection Limits for GC-MS Analysis of Bisphenol A and Four Other Bisphenols.

Solid phase extraction (SPE) of large volumes of water and beverage products was investigated for the GC-MS analysis of bisphenol A (BPA), bisphenol AF (BPAF), bisphenol F (BPF), bisphenol E (BPE), an...

The acute effect of coffee on endothelial function and glucose metabolism following a glucose load in healthy human volunteers.

A diet rich in plant polyphenols has been suggested to reduce the incidence of cardiovascular disease and type 2 diabetes mellitus, in part, via improvements in endothelial function. Coffee is a rich ...

Metabolism of fructose in B-cells: A C NMR spectroscopy based stable isotope tracer study.

Earlier studies on glucose metabolism in B-cells suggested an active TCA cycle in both naïve B cells and differentiated IgA plasma cells. Glycolysis was shown to be more active in IgA plasma cells th...

The effect of sugar-sweetened beverage price increases and educational messages on beverage purchasing behavior among adults.

There is a paucity of evidence regarding the impact of sugar sweetened beverage (SSB) price increases on beverage consumption, using individual-level data, for the population overall and for different...

Medical and Biotech [MESH] Definitions

A beverage prepared from SOYBEANS.

An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)

A beverage made by FERMENTATION of black tea and/or green tea.

Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.

A plant genus of the family RUBIACEAE. It is best known for the COFFEE beverage prepared from the beans (SEEDS).

More From BioPortfolio on "Effect of Dietary Fat When Eaten With Fructose Versus Glucose"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Hepatology
Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial