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Comparison of Ertapenem Distribution in the Muscle of Six Healthy Volunteers and Six Critically Ill Patients by Microdialysis

2014-08-27 03:16:13 | BioPortfolio

Summary

Ertapenem is an antibiotic that is highly bound to plasma protein (> 95%). The effects of this high protein binding on tissue distribution of antibiotics have been few evaluated yet.

In this study, two groups of subjects will be compared: 6 healthy volunteers and 6 critically ill patients (patients with infection due to an Ertapenem susceptible bacteria). Indeed, these 2 populations show changes in binding capacity of drugs to plasma proteins due to a decrease of protidaemia and of the affinity of drugs to transport proteins.

It seems therefore important to clarify the consequences of a modification in protein binding on distribution of antibiotics. That's why we have decided to characterize tissue distribution of ertapenem in healthy volunteers and critically ill patients by assessing: free and total concentrations in plasma and free concentrations in muscle by microdialysis.

Study Design

N/A

Conditions

Healthy

Intervention

Ertapeneme

Location

Poitiers University Hospital - 2 rue de la Milétrie - Réanimation chirugicale
Poitiers
France
86021

Status

Recruiting

Source

Poitiers University Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:13-0400

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