Tadalafil and Acetazolamide Versus Acetazolamide in Acute Mountain Sickness Prevention

2014-07-23 21:10:52 | BioPortfolio


To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.


A randomized controlled study comparing:

Tadalafil [20mg x1/day] and acetazolamide [125mg x2 day], versus Acetazolamide [125mg x2 day] alone, in trekkers to altitude > 3,000 m.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention


Pulmonary Edema


Tadalafil and acetazolamide, Acetazolamide


Center of Geographic Medicine
Tel Hashomer




Sheba Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:10:52-0400

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Medical and Biotech [MESH] Definitions

Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.


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