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Diesel Exhaust Inhalation, Systemic Nitric Oxide Inhibition and Cardiac Output

2014-08-27 03:16:14 | BioPortfolio

Summary

Exposure to combustion-derived fine particulate air pollution is associated with cardiovascular mortality and morbidity. In previous studies, exposure to diesel exhaust (a major constituent of urban particulate air pollution) has been shown to impair two important functions of the vascular endothelium: vascular vasomotor function and endogenous fibrinolysis. Our subsequent studies suggest this impairment of vascular function is mediated by a reduction in nitric oxide bioavailability. In this study we aim to investigate the cardiovascular responses to systemic nitric oxide synthase inhibition following exposure to dilute diesel exhaust.

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Conditions

Healthy

Intervention

Intravenous infusion of L-NMMA and Nor-epinephrine

Location

University Hospital Umeå
Umeå
Sweden

Status

Recruiting

Source

University of Edinburgh

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:16:14-0400

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